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All Journal Gema Lingkungan Kesehatan Indonesian Basic and Experimental Health Sciences
Ratnani, Daniela
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Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Role of Bleeding History: Mortality Risk Acute Leukimia Senaputra , Mas Aditya; Ariningrum, Dian; Immakulata Diah Pramudianti, Maria; Ratnani, Daniela; Sidharta, B. Rina Aninda; Eka Rezkita, Bastomy; Putri, Desi Puspa
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.293

Abstract

Acute leukemia is a malignant hematological disease with a low survival rate. The survival rate of acute leukemia patients is influenced by several factors, one of which is a history of bleeding. This study aimed to evaluate whether a history of bleeding constitutes an independent risk factor for mortality in patients diagnosed with acute leukemia at Dr. Moewardi Regional General Hospital, Surakarta. This study employed an observational and analytical retrospective cohort design. The subjects were patients diagnosed for the first time with acute leukemia by bone marrow puncture (BMP) and immunophenotyping from January to December 2023. The data was analyzed using chi-square for bivariate analysis and multivariate logistic regression. Survival analysis was performed using the Kaplan-Meier test. A total of 124 patients were included in the analysis. Bivariate analysis demonstrated that both history of bleeding (p = 0.008) and leukocyte count (p = 0.001) were significantly associated with mortality. Multivariate logistic regression confirmed that a history of bleeding (p = 0.027; relative risk [RR] = 3.45) and leukocyte count exceeding 50,000 cells/μL (p = 0.002; RR = 5.10) were independently associated with reduced survival. Kaplan-Meier survival curves showed lower cumulative survival among patients with a history of bleeding and those with elevated leukocyte counts. A history of bleeding is an independent risk factor for decreased survival in patients with acute leukemia at Dr. Moewardi Regional General Hospital. Additionally, leukocyte counts exceeding 50,000 cells/μL are associated with significantly worse survival outcomes.
Low Serum Anti Mullerian Hormone as a Risk Factor for Cardiovascular Disease in Child-Bearing Age Women Ratnani, Daniela; Pramudianti, M.I. Diah
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 1 (2025): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss1pp80-88

Abstract

IntroductionCardiovascular disease (CVD) is the leading cause of global death. Incidence of having CVD is influenced by general risk factors and gender-related risk (preeclampsia, miscarriage, premature birth, contraception and hormonal therapy). Women of childbearing age have lower risk of CVD than men. Anti Mullerian Hormone (AMH) can be used to predict CVD. This study aimed to know association between Serum AMH level with CVD. MethodsThis study was an observational analytic, cross-sectional study. Subjects study is women with childbearing age (18-44 years old) who doing laboratory examination from May until November 2024. The exclusion criteria were patients who under chemoradiation therapy, pregnancy and have history of fertility disorder such as polycystic ovarian syndrome (PCOS). Data was subjected to bivariate testung chi square and multivariate regression logistic with Statistical Package for the Sociak Sciences (SPSS) version 29.0. ResultsA total of 57 subjects were being analyzed. Bivariate analysis showed that Serum AMH (p<0,001) have correlation with CVD. Multivariate analysis shows that Serum AMH <0,69 ng/mL (p<0,001; RR=34,049) were independently associated with CVD. ConclusionsSerum AMH <0,69 ng/mL (PR:34,05; 95% CI: 6,245–185,630, p=<0,001) increased risk of having CVD in women with childbearing age.
Co-Authors Ariningrum, Dian Eka Rezkita, Bastomy Immakulata Diah Pramudianti, Maria Pramudianti, M.I. Diah Putri, Desi Puspa Senaputra , Mas Aditya Sidharta, B. Rina Aninda