Article Per Year (5 Year)
p-Index From 2021 - 2026
0.562
P-Index
This Author published in this journals
All Journal Biology, Medicine, & Natural Product Chemistry
Osigwe, Chinyelu C.
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Antiinflammatory and Antipyretic Activities of Stem Extract and Fractions of Telfairia occidentalis in Rodents Okokon, Jude E; Osigwe, Chinyelu C.; Florence, Uwaeme Ugonma; Andrew, Ukeme Essien
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.473-479

Abstract

Telfairia occidentalis Hook (Family-Cucurbitaceae) is a vegetable employed in Ibibio traditional medicine for the treatment of various diseases such as malaria and fever among others. The stem extract of Telfairia occidentalis was investigated for antiinflammatory and antipyretic activities in rodents using various experimental models.The stem extract (200 –600 mg/kg) of T. occidentalis was investigated for antiinflammatory activity against carrageenin, egg albumin and xylene – induced edema models and antipyretic activity against D-amphetamine, 2,4-dinitrophenol and yeast-induced pyrexia models.  The extract caused a significant (p<0.05 – 0.001) dose-dependent reduction of inflammation caused by different phlogistic agents used. These effects were comparable to those of the standard drug, (ASA, 100 mg/kg) used in some cases. The extract also exerted prominent inhibition of pyrexia on amphetamine and dinitrophenol-induced pyrexia (5 h). Inhibition was significant (p<0.05–0.001) from 3 to 5 h post- administration of extract and in a dose-dependent fashion. However, the stem extract did not affect yeast-induced pyrexia in mice. The anti-inflammatory and antipyretic effects of this plant may in part be mediated through the chemical constituents of the plant. The findings of this work confirm the ethnomedical uses of this plant to treat inflammatory and febrile conditions.
Antipyretic Activity of Stembark Extract of Mammea africana in Rats Okokon, Jude E.; Osigwe, Chinyelu C.; Udobang, John A; Florence, Uwaeme Ugonma
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1009-1013

Abstract

Mammea africana Sabine (Guttiferae), is a tree plant whose parts are variously used locally for the treatment of various diseases such as malaria and fever among others. The stembark extract of M. africana (30 -90 mg/kg) was investigated for antipyretic activity in rats using different experimental models; amphetamine, dinitrophenol and yeast-induced pyrexia. The extract exerted prominent inhibition of pyrexia on amphetamine, dinitrophenol and yeast -induced pyrexia. Inhibition was significant (p<0.05–0.001) from 3 to 5 h post- administration of extract and in a dose-dependent fashion. The antipyretic effects of this plant may in part be mediated through the chemical constituents of the plant. The results of this investigation validate the ethnomedical uses of this plant in the treatment of febrile conditions.
Hepatoprotective Activities of Seed Extract and Fractions of Telfairia occidentalis on Doxorubicin-Induced Hepatotoxicity in Rats Nwosu, Ugochi Queenette; Osigwe, Chinyelu C.; Uwaeme, Ugonma Florence; Fabian, Unyime A.; Okokon, Jude Efiom
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1529-1536

Abstract

Telfairia occidentalis Hook (cucurbitaceae) seeds, which is used in the preparation of soups and as medicine traditionally to treat various diseases by the Ibibios was investigated for effect against doxorubicin-induced hepatotoxicity. The seed extract (138 -553 mg/kg) and fractions; dichloromethane (DCM) and aqueous, 276 mg/kg) were evaluated for hepatoprotective activity against doxorubicin-induced liver injury in rats. Liver function parameters, liver oxidative stress markers and liver histology were used to assess the liver protective potential of the extract and fractions. The seed extract and fractions significantly (p<0.05-0.01) reduced the serum levels of AST, ALT, ALP, total and direct bilirubin that were elevated by doxorubincin. Also, the reduced levels of total protein and albumin by doxorubicin were increased by the extract coadministration. The levels of GSH, GST, SOD, GPx, and CAT that were decreased by doxorubicin were significantly (p<0.01) elevated and raised MDA level was reduced by the seed extract and fractions. Histology of the liver sections of extract -treated animals showed reductions in the pathological features compared to the organotoxic-treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective potential. The anti-toxic effect of this plant may in part be mediated through the chemical constituents of the plant. The seeds of Telfairia occidentalis possess anti-toxicant properties which can be exploited in the treatment of doxorubicin related toxicities.
Co-Authors Andrew, Ukeme Essien Fabian, Unyime A. Florence, Uwaeme Ugonma Nwosu, Ugochi Queenette Okokon, Jude E Okokon, Jude E. Okokon, Jude Efiom Udobang, John A Uwaeme, Ugonma Florence