Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Jurnal Respirasi (JR) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Widiastara, Antonio Ayrton
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Emerging Resistance to Albendazole in Soil-Transmitted Helminths Widiastara, Antonio Ayrton; Lucas, Amalia Margaretha; da Gama, Laura Boavida; Guterres, Basiraldo Baru; Ferreira, Esmeraldito; Gomes Fernandes, Sergio Herminio
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.71299

Abstract

Soil-transmitted helminths (STHs) are significant pathogens affecting approximately 1.5 billion people globally, with the highest prevalence in sub-Saharan Africa, South America, and Asia. This study examined the effectiveness of albendazole, a widely used anthelminthic drug, in treating STH infections, particularly focusing on its potential resistance. Despite its effectiveness in many cases, recent studies have indicated a concerning trend of reduced efficacy, particularly against species such as Trichuris trichiura. This study reviewed literature from the past decade, identifying key studies that demonstrate a decline in albendazole’s effectiveness across various populations, including school-aged children in multiple regions. The findings proposed that while albendazole remains the primary treatment option, its effectiveness varies significantly based on geographic and demographic factors, raising concerns about the emergence of drug resistance. This study emphasizes the need for ongoing monitoring and potential pharmacological combinations to enhance treatment efficacy and address the threat of resistance. Ultimately, the research highlights the complexity of managing STH infections and the necessity for tailored intervention strategies.   Highlights: 1. Although albendazole is a commonly used medication for soil-transmitted helminths (STHs), its efficacy seems to be waning, thereby requiring additional research to analyze potential resistance. 2. Many studies have pointed out a decreased efficacy of albendazole, despite none having verified resistance, indicating that the medication remains efficacious in specific groups, geographical areas, and dosage regimens where STH infections are prevalent.
Pneumoascariasis: Ascaris Worm Infestation in the Lungs Widiastara, Antonio Ayrton; Ferreira, Esmeraldito; Basuki, Sukmawati
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.69-75

Abstract

Pneumoascariasis is an infestation from one of the most common worms or helminths found on earth in the respiratory system. The worm is called Ascaris lumbricoides, which penetrates and infests the human body through the fecal-oral process. The fertilized Ascaris ova, or simply egg, would develop into larvae, which then move to the liver and lungs through the portal vein system. These larvae will soon develop into mature worms in the human respiratory system, inside the lungs, particularly in the bronchioles. These Ascaris larvae trigger common symptoms such as persistent cough, shortness of breath, and wheezing. To diagnose this condition, supplementary examinations are necessary since it is difficult to diagnose only by history taking and some physical exams. Additional exams include chest X-rays that, at one point, display lung infiltration. The chest computed tomography (CT) scan shows ground-glass opacity and a classic inflammation marker called Charcot-Leyden crystals that are most likely present. Pneumoascariasis is often misinterpreted and misdiagnosed. Therefore, this literature review was made to further understand about pneumoascariasis.
Co-Authors da Gama, Laura Boavida Ferreira, Esmeraldito Gomes Fernandes, Sergio Herminio Guterres, Basiraldo Baru Lucas, Amalia Margaretha Sukmawati Basuki