This study was conducted to examine the impact of work motivation and organizational commitment on employee performance with OCB as an intermediate variable, at PKU Muhammadiyah Purbalingga Hospital. Using a quantitative approach, the data in this study was obtained from the results of a questionnaire on 121 employees from a total population of 223 people who were selected by aksinally using the Slovin formula. The data was analyzed using SEM-based Partial Least Square (PLS) through Smart PLS 4.00 software. The results revealed: (1) work motivation significantly had a positive effect on OCB and employee performance; (2) organizational commitment significantly has a positive effect on OCB and performance; (3) OCB is able to effectively mediate between work motivation and organizational commitment and performance; and (4) OCB itself has been proven to improve employee performance.