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All Journal Interdental Jurnal Kedokteran Gigi (IJKG)
Ma’ruf, Mochammad Taha
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Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Public Health

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Effectiveness of Cengkeh Leaf Extract Ointment (Syzygium Aromaticum L.) on The Number of Fibroblast Cells on Healing of Injection Wistar Walls (Rattus norvegicus) Poernomo, Hendri; Ma’ruf, Mochammad Taha; Mbiliyora, Paskarani
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.12058

Abstract

Introduction: An open wound is a condition where part of the body's tissue has been damaged from its normal state due to sharp or blunt trauma, changes in temperature, chemicals, explosions, electric shock, or animal bites. Clove leaves contain active ingredients such as eugenol, saponins, phenols, steroids, terpenoids, alkaloids, flavonoids, and tannins, as well as essential oils, which have the potential to be anti-inflammatory, antibacterial, and analgesic, inhibiting cell damage and accelerating the healing process in wounds. Materials and Methods: This type of research is an in vivo laboratory experiment with a posttest-only control group design and sample grouping using a Completely Randomized Design (CRD). The treatment was carried out for 5 days by applying it to the mice's backs twice a day, then on the 6th day, decapitation was carried out, taking specimens to observe the number of fibroblast cells. Results and Discussions: The research was analyzed using one-way ANOVA followed by the Least Significant Difference (LSD) test. The results of the study showed that administering cloveleaf extract ointment (Syzygium Aromaticum L.) with concentrations of 3%, 6% and 9% was effective in increasing the number of fibroblast cells in the healing process of incisional wounds on the backs of Wistar rats (Rattus norvegicus). Conclusion: Giving cloveleaf extract ointment at a concentration of 3% is more effective in increasing the number of fibroblast cells in the healing process of incisional wounds in mice compared to concentrations of 6% and 9%.
Advantages and Limitations of Nanomaterials in Restorative and Endodontic Treatments: A Literature Review Ma’ruf, Mochammad Taha; Sidiqa, Atia Nurul; Yudistian, Ilma
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 1 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i1.13837

Abstract

Introduction: Nanotechnology has transformed dentistry by introducing nanomaterials with superior mechanical properties, improved aesthetics, and enhanced antibacterial effects, thereby improving treatment outcomes. These materials have been widely adopted in modern dental treatments. However, concerns remain regarding their potential toxicity, production costs, and long-term effects on human health and the environment. This review explores the benefits and challenges of nanomaterials in dentistry, particularly their applications in restorative and endodontic treatments. It examines potential risks to provide a balanced perspective on their clinical use. Review: Nanomaterials enhance the strength and durability of dental restorations while reducing bacterial adhesion. In endodontics, nanomaterials enhance the antimicrobial activity and penetration of root canal sealers, thereby improving root canal disinfection and reducing the risk of reinfection. However, prolonged exposure to nanomaterials raises concerns about biocompatibility, oxidative stress, immune responses, and neurotoxicity. Current studies highlight the need for standardized safety protocols and long-term clinical trials. Conclusion: Nanotechnology offers significant advancements in dentistry, improving treatment durability and patient outcomes. However, further research is required to assess long-term safety, optimize materials for clinical use, and develop regulatory guidelines. Ensuring the biocompatibility and environmental safety of nanomaterials is a priority for their widespread adoption.
Co-Authors Atia Nurul Sidiqa Hendri Poernomo Mbiliyora, Paskarani Yudistian, Ilma