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All Journal Indonesian Journal of Chemistry
Dang, Giao Huynh
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Chemical Engineering, Chemistry & Bioengineering Chemistry

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Identification of Anti-Inflammatory Components from Launaea sarmentosa Using In Vitro Cell Model Nguyen, Thanh Quoc Chau; Vo, Khang Thanh; Duong, Cua Dinh; Huynh, Toan Phu; Ca, Lieu Thi Thuy; Dang, Giao Huynh
Indonesian Journal of Chemistry Vol 25, No 4 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.103167

Abstract

Launaea sarmentosa (Willd.) Kuntze, a medicinal herb known for treating inflammatory diseases, was examined for its anti-inflammatory compounds to identify novel therapies. This study indicated that hexane and ethyl acetate fractional extracts significantly reduced NO secretion in LPS-stimulated RAW264.7 macrophages, indicating the presence of potential anti-inflammatory compounds. Additionally, four anti-inflammatory compounds, including taraxasteryl acetate (1), esculetin (2), pyrimidine-2,4-dione (3), and 5-hydroxypryrolidin-2-one (4), were isolated, and their structures were characterized using 1D and 2D-NMR. This study marked the first report of taraxasteryl acetate, pyrimidine-2,4-dione, and 5-hydroxypryrolidin-2-one being isolated from this species. Furthermore, these compounds exerted their anti-inflammatory role by inhibiting NO production and TNF-α expression. Thus, this study contributes to identifying anti-inflammatory constituents from L. sarmentosa and highlights a potential approach for developing phytotherapeutic agents.
Co-Authors Ca, Lieu Thi Thuy Duong, Cua Dinh Huynh, Toan Phu Nguyen, Thanh Quoc Chau Vo, Khang Thanh