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All Journal Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Jurnal Kesehatan dr. Soebandi
Iwan Santoso, Blegoh
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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ANALISIS JEJARING FARMAKOLOGI SENYAWA METABOLIT SEKUNDER DAUN SUNGKAI (Peronema canescens) TERHADAP JALUR NF-κB DAN IL-6 DALAM PERADANGAN KRONIS Iwan Santoso, Blegoh; Zaini, Muhammad
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 7 No 1 (2025)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v7i1.243

Abstract

The potential of Peronema canescens (sungkai) leaf as a natural anti-inflammatory agent is increasingly studied due to its abundant secondary metabolites. This study aimed to investigate the interaction of sungkai leaf compounds with inflammation-related targets, especially NF-κB and IL-6, using pharmacological network analysis. Compounds were obtained from databases and literature, then analyzed through SwissTargetPrediction. The targets were visualized using String to identify networks between bioactive compounds and key inflammatory pathways. Results showed that flavonoids and terpenoids in sungkai interact with targets that regulate NF-κB and IL-6 signaling. The network also revealed key nodes such as TNF, IL1B, and MAPK8 as central mediators. These findings indicate that sungkai leaves have potential as a multi-target anti-inflammatory agent through modulation of inflammatory networks. Further validation through in vitro and in vivo studies is recommended.
In Silico Study of Bay Leaf (Syzygium polyanthum) Compounds as Renin Inhibitors and Antihypertensive Herbal Tea Development Iwan Santoso, Blegoh; Nur Hikmah, Siti; Robitah, ahmad; Agung Cendikiawan, Khrisna; Kintoko
Jurnal Kesehatan dr. Soebandi Vol 14 No 1 (2026): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v14i1.1112

Abstract

Background :  Hypertension is a major global health problem contributing significantly to cardiovascular morbidity and mortality. One of the key pathways in blood pressure regulation is the Renin–Angiotensin– Aldosterone System (RAAS), where renin plays a crucial role as the initiating enzyme. Inhibition of renin is considered a more specific therapeutic strategy with potentially fewer side effects. Bay leaf (Syzygium polyanthum) has been traditionally used as an antihypertensive agent and contains various bioactive compounds Methods : This study aims to evaluate the potential of bay leaf compounds as renin inhibitors using an in silico approach and to explore their development into herbal tea products. Active compounds were identified through literature-based LC-MS data, including gallic acid, malic acid, luteic acid, and myricetin. Molecular docking was performed using AutoDock Vina against human renin (PDB ID: 3D91). Results: The results showed that myricetin exhibited the highest binding affinity (-9.3 kcal/mol), followed by luteic acid (-7.9 kcal/mol), gallic acid (-6.1 kcal/mol), and malic acid (- 5.1 kcal/mol), compared to the standard inhibitor remikiren (-10.3 kcal/mol). Conclusions: Interaction analysis revealed that myricetin formed multiple hydrogen bonds with catalytic residues. These findings suggest that bay leaf compounds, especially myricetin, have potential as natural renin inhibitors and could be developed as antihypertensive herbal tea.
Co-Authors Agung Cendikiawan, Khrisna Kintoko Muhammad Zaini Nur Hikmah, Siti Robitah, ahmad