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All Journal Pharmacology and Clinical Pharmacy Research Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Jurnal Pharmacia Mandala Waluya
Widya Norma Insani
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Padjadjaran, Sumedang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Effectiveness of Pharmacist-Led Intervention for Hepatitis C Patients - A Systematic Review Surya, Geraldo; Angelica, Angelica; Amalia, Zerra Rizki; Nisrina, Diflaa Kayla; Insani, Widya Norma
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.64176

Abstract

Background: Pharmacist-led interventions, encompassing patient education, adherence monitoring, and personalized care, have emerged as a critical strategy to optimize treatment outcomes in Hepatitis C (HCV) management, particularly in improving Sustained Virologic Response (SVR) and mitigating drug-related challenges.Objective: This review assesses the impact of pharmacist-led interventions on key HCV patient outcomes, including SVR rates, medication adherence, and the management of Adverse Drug Reactions (ADRs) and Drug-Drug Interactions (DDIs).Methods: A systematic search was conducted on PubMed database for studies published between January 2000 and December 2024, following PRISMA guidelines. The search included Randomized Controlled Trials (RCTs), cohort, and retrospective studies. An initial search identified 192 records, from which 12 studies were included in the review. Result: In hepatitis C management, pharmacists intervened in many ways including direct close monitoring, patient education, and individualized care which led to enhanced clinical outcomes and improved patient engagement. Most included studies, both RCTs and Observational studies showcased high SVR rates. Some studies that demonstrated lower SVR rates or did not differ significantly from the control group were due to more complex patient demographics.  Recorded improvements also included medication adherence, patient engagement, and effective management of ADRs and DDIs. Conclusion: The findings indicate that pharmacist-led interventions demonstrated predominantly positive impacts on clinical outcomes. However, the evidence is limited by variations in study design and shortage of RCTs. Further research with standardized protocols is recommended to better define the role of pharmacists in HCV care.
Unintended Medication Discrepancies (UMD) Pada Saat Rekonsiliasi Transfer dalam Konteks Negara Berpenghasilan Rendah dan Menengah : Tinjauan Naratif Husain, Aprilia; Khairinisa , Miski Aghnia; Insani , Widya Norma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.983

Abstract

Unintended medication discrepancies (UMD) frequently occur during transitions of care, particularly in low- and middle-income countries (LMICs), where the healthcare system often lacks standardized protocols, integrated information systems, and trained clinical pharmacists. This narrative review aims to explore the prevalence, characteristics, and contributing factors of UMD across LMICs based on analysis of 10 selected studies. Omission was the most frequently reported type of discrepancy, especially among elderly patients with complex therapy regimens. Factors influencing the occurrence of UMD include polypharmacy, inadequate documentation, absence of medication reconciliation protocols, limited pharmacist involvement, and poor inter-facility communication. Despite systemic limitations, studies demonstrate that pharmacist-led interventions can significantly reduce the incidence of UMD, even in resource-limited settings. Comparative analysis with studies from developed countries reveals that digital tools, standardized policies, and integrated pharmacist roles greatly enhance medication safety during transitions of care. The review concludes that addressing UMD in LMICs requires a multi-faceted approach, including national policy development, pharmacist integration into clinical teams, implementation of context-appropriate digital systems, and strengthening pharmacy education. These strategies are crucial for improving patient safety and reducing preventable adverse drug events related to medication discrepancies.
The Role of Pharmacists in Preventing Antibiotic Resistance: A Narrative Review Martadiani, Kristy Rahayu; Insani, Widya Norma; Alfian, Sofa Dewi
Pharmaceutical Sciences and Research Vol. 12, No. 3
Publisher : UI Scholars Hub

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Abstract

Antibiotic resistance is a serious global health threat, driven by irrational antibiotic use, including uncontrolled self-medication, use without proper indication, and non-adherence to medical instructions. This review aims to examine the strategic role of pharmacists in preventing antibiotic resistance through interventions at different points of healthcare services. While the discussion addresses the global pharmacist role, this review places particular emphasis on resource-limited settings, such as those in developing countries, where access to antibiotics is relatively unrestricted, regulatory enforcement is weak, and self-medication practices are more prevalent. Literature findings indicate that pharmacists play an important role as educators and supervisors of medication use, as well as partners in antimicrobial stewardship programs. In the context of self-medication, pharmacists play a key role in refusing requests for antibiotics without a prescription and in raising patient awareness. In hospital settings, clinical pharmacists are involved in validating therapeutic indications, recommending de-escalation, and ensuring adherence to evidence-based treatment guidelines. Recent studies, including those in Indonesia, have shown that active pharmacist involvement can reduce inappropriate antibiotic use and enhance patient adherence to therapy. Improved adherence significantly contributes to resistance prevention. Therefore, strengthening pharmacist capacity and regulatory support are key components in both national and global strategies to combat antimicrobial resistance.
Efektivitas Intervensi Program Penatagunaan Antimikroba dalam Mengoptimalkan Penggunaan Antibiotik: Narrative Review Fadilah; R. Mersa Nurain Kausar; Widya Norma Insani; Ivan Surya Pradipta
Jurnal Pharmacia Mandala Waluya Vol. 5 No. 4 (2026): Jurnal Pharmacia Mandala Waluya
Publisher : Prodi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54883/jpmw.v5i4.758

Abstract

Penggunaan antibiotik yang tidak rasional masih menjadi permasalahan global yang signifikan dan berkontribusi terhadap mening katnya resistensi antimikroba. Program penatagunaan antimikroba (Antimicrobial Stewardship Program/ASP) dikembangkan sebagai strategi sistematis untuk mengoptimalkan penggunaan antibiotik melalui berbagai pendekatan intervensi, termasuk intervensi multifaset, edukasi, audit dan umpan balik, serta clinical decision support (CDS) berbasis teknologi. Narrative review ini bertujuan untuk mengevaluasi efektivitas berbagai intervensi ASP (Antimicrobial Stewardship Program) dalam meningkatkan penggunaan antibiotik yang rasional di berbagai fasilitas pelayanan kesehatan. Pencarian literatur dilakukan melalui basis data PubMed dan Scopus terhadap artikel yang dipublikasikan pada periode 2016–2026. Artikel yang diinklusi merupakan randomized controlled trial (RCT) berbahasa Inggris yang mengevaluasi intervensi ASP dan melaporkan luaran terkait penggunaan antibiotik. Sebanyak tujuh studi memenuhi kriteria dan dianalisis menggunakan sintesis naratif berdasarkan jenis intervensi, setting pelayanan, dan luaran yang dilaporkan. Hasil menunjukkan bahwa efektivitas intervensi ASP bervariasi. Intervensi multifaset yang mengombinasikan edukasi, pedoman klinis, dukungan pengambilan keputusan, serta Prospective Audit andFeedback (PAF) cenderung menunjukkan hasil yang lebih konsisten dalam memperbaiki ketepatan penggunaan antibiotik. PAF menunjukkan potensi dalam mengurangi penggunaan antibiotik tanpa memperburuk luaran klinis pada populasi yang diteliti, sedangkan intervensi berbasis CDS menunjukkan hasil yang bervariasi dan dipengaruhi oleh integrasi sistem, alur kerja klinis, serta penerimaan klinisi. Diagnostik cepat dapat meningkatkan ketepatan terapi antibiotik secara dini, tetapi perbaikan luaran penatagunaan antimikroba tidak selalu disertai dengan perbaikanluaran klinis. Heterogenitas jenis intervensi, populasi, setting pelayanan, dan luaran membatasi perbandingan langsung serta generalisasi hasil. Dengan demikian, efektivitas strategi ASP tidak bersifat universal pada berbagai setting pelayanan kesehatan. Strategi yang diterapkan perlu disesuaikan dengan karakteristik pelayanan, kapasitas sumber daya, dan konteks implementasi pada masing-masing fasilitas kesehatan.
Co-Authors Amalia, Zerra Rizki Angelica, Angelica Fadilah Husain, Aprilia Ivan Surya Pradipta Martadiani, Kristy Rahayu Miski Aghnia Khairinisa Nisrina, Diflaa Kayla R. Mersa Nurain Kausar Sofa Dewi Alfian Surya, Geraldo