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All Journal Pharmacology and Clinical Pharmacy Research Pharmaceutical Sciences and Research (PSR)
Insani, Widya Norma
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Medicine & Pharmacology

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Effectiveness of Pharmacist-Led Intervention for Hepatitis C Patients - A Systematic Review Surya, Geraldo; Angelica, Angelica; Amalia, Zerra Rizki; Nisrina, Diflaa Kayla; Insani, Widya Norma
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.64176

Abstract

Background: Pharmacist-led interventions, encompassing patient education, adherence monitoring, and personalized care, have emerged as a critical strategy to optimize treatment outcomes in Hepatitis C (HCV) management, particularly in improving Sustained Virologic Response (SVR) and mitigating drug-related challenges.Objective: This review assesses the impact of pharmacist-led interventions on key HCV patient outcomes, including SVR rates, medication adherence, and the management of Adverse Drug Reactions (ADRs) and Drug-Drug Interactions (DDIs).Methods: A systematic search was conducted on PubMed database for studies published between January 2000 and December 2024, following PRISMA guidelines. The search included Randomized Controlled Trials (RCTs), cohort, and retrospective studies. An initial search identified 192 records, from which 12 studies were included in the review. Result: In hepatitis C management, pharmacists intervened in many ways including direct close monitoring, patient education, and individualized care which led to enhanced clinical outcomes and improved patient engagement. Most included studies, both RCTs and Observational studies showcased high SVR rates. Some studies that demonstrated lower SVR rates or did not differ significantly from the control group were due to more complex patient demographics.  Recorded improvements also included medication adherence, patient engagement, and effective management of ADRs and DDIs. Conclusion: The findings indicate that pharmacist-led interventions demonstrated predominantly positive impacts on clinical outcomes. However, the evidence is limited by variations in study design and shortage of RCTs. Further research with standardized protocols is recommended to better define the role of pharmacists in HCV care.
The Role of Pharmacists in Preventing Antibiotic Resistance: A Narrative Review Martadiani, Kristy Rahayu; Insani, Widya Norma; Alfian, Sofa Dewi
Pharmaceutical Sciences and Research Vol. 12, No. 3
Publisher : UI Scholars Hub

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Abstract

Antibiotic resistance is a serious global health threat, driven by irrational antibiotic use, including uncontrolled self-medication, use without proper indication, and non-adherence to medical instructions. This review aims to examine the strategic role of pharmacists in preventing antibiotic resistance through interventions at different points of healthcare services. While the discussion addresses the global pharmacist role, this review places particular emphasis on resource-limited settings, such as those in developing countries, where access to antibiotics is relatively unrestricted, regulatory enforcement is weak, and self-medication practices are more prevalent. Literature findings indicate that pharmacists play an important role as educators and supervisors of medication use, as well as partners in antimicrobial stewardship programs. In the context of self-medication, pharmacists play a key role in refusing requests for antibiotics without a prescription and in raising patient awareness. In hospital settings, clinical pharmacists are involved in validating therapeutic indications, recommending de-escalation, and ensuring adherence to evidence-based treatment guidelines. Recent studies, including those in Indonesia, have shown that active pharmacist involvement can reduce inappropriate antibiotic use and enhance patient adherence to therapy. Improved adherence significantly contributes to resistance prevention. Therefore, strengthening pharmacist capacity and regulatory support are key components in both national and global strategies to combat antimicrobial resistance.
Co-Authors Amalia, Zerra Rizki Angelica, Angelica Martadiani, Kristy Rahayu Nisrina, Diflaa Kayla Sofa Dewi Alfian Surya, Geraldo