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All Journal Jurnal Respirologi Indonesia Malang Respiratory Journal
Yaman, Muli
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Path Analysis in PLS for Assessing the Impact of Metabolic Syndrome on Pulmonary Fibrosis in a Rat Model Yaman, Muli; Djajalaksana, Susanthy; Putra, Ngakan Putu Parsama; Yudhanto, Hendy Setyo
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.889

Abstract

Background: Metabolic syndrome (MetS) is characterized by obesity, dyslipidemia, hyperglycemia, and insulin resistance, which are associated with increased risk for pulmonary fibrosis. This study investigates the impact of MetS on pulmonary fibrosis in a rat model using Partial Least Squares (PLS) path analysis. Methods: Sprague Dawley rats were fed a high-fat, high-fructose diet for 37 weeks to induce MetS. Key metabolic parameters, including body weight, lipid profiles, fasting blood glucose, fibrosis markers and Aschroft scores, were assessed. PLS path analysis was conducted to explore the relationships between these variables and their influence on pulmonary fibrosis. Results: PLS path analysis identified a strong correlation between increased body weight and MetS development (path coefficient=0.977). Dyslipidemia, characterized by elevated triglycerides and reduced HDL cholesterol, was also associated with MetS. A novel association was found between glucose dysregulation and pulmonary fibrosis (R2=0.908; path coefficient=0.947), suggesting that hyperglycemia contributes to lung fibrosis. Reduced PPARγ expression was associated with insulin resistance and inflammation, implicating it in fibrotic processes. Conclusion: This study highlights the role of metabolic disturbances in promoting pulmonary fibrosis in MetS. PLS path analysis effectively identified key metabolic pathways, suggesting potential targets for therapeutic intervention to mitigate MetS effects and prevent fibrosis. Further research is warranted to explore these pathways and develop targeted therapies.
Successful Embolization in Recurrent Hemoptysis Caused by Pulmonary Aspergilloma: A Case Report: Successful Embolization in Recurrent Hemoptysis Caused by Pulmonary Aspergilloma Yaman, Muli; Sugiri, Jane; Putra, Ngakan; Santosaningsih, Dewi; Aslam, Achmad
Malang Respiratory Journal Vol. 5 No. 1 (2023): Volume 5 No 1, March 2023
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2023.005.01.4

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Background: Aspergilloma is a fungal infection that can cause recurrent hemoptysis. One of the treatment modalities is embolization, which has a success rate of 85% to 100%, although the recurrence rate may reach 10% to 33%. Case Illustration: A 29-year-old female came to the emergency ward with recurrent hemoptysis. She had a history of tuberculosis with completed treatment 7 years ago. Chest radiography showed left lung tuberculosis with emphysematous lung. Chest CT with contrast revealed an air-crescent sign, and culture from bronchoalveolar lavage (BAL) showed Aspergillus spp. Then, she was diagnosed with pulmonary aspergilloma. Embolization was performed in the left internal mammary artery, and the blushing was decreased by 80%. However, the hemoptysis was still recurrent; a second embolization was performed in the left supreme intercostal artery, costocervical trunk artery, and bronchial artery, resulting in no blushing. The patient had no further episodes of hemoptysis, and her antifungal therapy was changed from fluconazole to voriconazole. Discussion: Recurrent hemoptysis can be caused by pulmonary aspergilloma. Embolization is usually done to reduce bleeding before surgery. The patient had performed embolization 2 times with no further episodes of hemoptysis. Surgical resection as a definitive treatment was recommended in this case, but the patient refused. Therefore, the patient’s management was optimized using voriconazole and embolization for the hemoptysis. Conclusion: Management of recurrent hemoptysis in patients with aspergilloma may include embolization and antifungal treatment which give improved clinical outcomes. Keywords: recurrent hemoptysis, embolization, aspergilloma, tuberculosis
Co-Authors Aslam, Achmad Dewi Santosaningsih Djajalaksana, Susanthy Putra, Ngakan Putra, Ngakan Putu Parsama Sugiri, Jane Yudhanto, Hendy Setyo