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All Journal Paediatrica Indonesiana Jurnal EduHealth Jurnal Sehat Indonesia (JUSINDO) Jurnal Vokasi Kesehatan
Fiona Paramitha
Fakultas Kedokteran, Universitas Negeri Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Role of vitamin D3 on IL-17 expression in colon and improvement of colonic mucosa in an inflammatory bowel disease mice model Fiona Paramitha; Satrio Wibowo
Paediatrica Indonesiana Vol 63 No 1sup (2023): Supplementary Issue March 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.1sup.2023.1-7

Abstract

Background Inflammatory bowel disease (IBD) is an inflammation due to a Th1/Th2 regulatory imbalance and a Th17/Treg transformation imbalance which then releases inflammatory mediators, such as interleukin-17. The administration of vitamin D has the potential to prevent the inflammation in IBD. Objective To evaluate a possible role of vitamin D3 in reducing IL-17 expression and colonic mucosal repair in an IBD mice model. Methods The study used male BALB/c mice, 8-10 weeks old, weighing 20-25 grams, divided randomly into five groups with 8 mices in each group. The experimental mice were given 5% dextran sulfate sodium (DSS) on days 1-7 to induce colitis, and then were given vitamin D3 on days 8-14. Group 1 was the control group; Group 2 was given 5% DSS; Group 3 was given 5% DSS and vitamin D3 0.2 mcg/25 g body weight; Group 4 was given 5% DSS and vitamin D3 0.4 mcg/25 g body weight; and Group 5 was given 5% DSS and vitamin D3 0.6 mcg/25 g body weight. On day 15, the mice underwent euthanasia and colonic retrieval. Parameters assessed were IL-17 expression (immunohistochemical, with monoclonal antibody against IL-17) and colonic histology improvement, using the mouse colitis histology index (MCHI) score. Results The IL-17 expression measured by immunohistochemistry increased significantly in only 5% DSS group. There was a significant decrease in MCHI scores in the groups given vitamin D3, where the greater the dose of vitamin D3 given, the lower the MCHI score. Interleukin-17 expression had positive strong correlation with MCHI (r=0.985; P=0.002) Conclusion The improvement of colonic mucosal damage based on MCHI score was significant in groups given vitamin D3. There is a significant correlation between IL-17 reduction and colonic mucosal repair in IBD mice.
The Effects of Early Initiation of Breastfeeding and Exclusive Breastfeeding on Stunting among Children Under Five: A Systematic Review Paramitha, Fiona
Jurnal Vokasi Kesehatan Vol 4 No 1 (2025)
Publisher : Gayaku Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/juvokes.v4i1.1388

Abstract

This systematic review aims to synthesize and critically appraise the evidence on the association between early initiation of breastfeeding (EIBF) and exclusive breastfeeding (EBF) with the incidence of stunting in children under five years of age. A comprehensive search was conducted through Semantic Scholar and related databases up to April 2024. Selection, data extraction, and methodological quality assessment followed PRISMA guidelines and were conducted independently by two reviewers. Results were synthesized narratively due to heterogeneity of included studies. Of 1,500 articles identified, 1,050 were screened after removal of duplicates. After screening titles and abstracts, 80 full-text articles were assessed, and 40 studies were included in the synthesis. Most studies showed a significant protective effect of both EIBF and EBF against stunting, with odds ratios for stunting in non-EBF children ranging from 4.08 to 21.0. Delayed EIBF increased the risk of stunting with some studies reporting odds ratios up to 9.14. Meta-analyses confirmed this protective association with pooled adjusted odds ratios for EBF around 0.73. Early initiation and exclusive breastfeeding for the first six months are proven, low-cost, and scalable interventions for reducing stunting risk in children under five.
Effectiveness of Interactive Education on Cardiovascular Risk in Increasing Knowledge of Reproductive Age Women for Prevention of Pregnancy Complications Fiona Paramitha; Alviannur Halim; Tri Putra Rahmad Ramadani; Erick Tanara; Rahmantio Adi; Iman Rachmanto
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Pregnancy complications related to cardiovascular disease are a significant cause of maternal morbidity and mortality in Indonesia, exacerbated by low health literacy among women of reproductive age. Effective education is a key intervention, but the most impactful model still needs to be explored. This study aims to evaluate the effectiveness of a multimedia-based interactive education program in increasing knowledge about cardiovascular risk as a preventive measure for pregnancy complications in women of reproductive age. This study uses a quasi-experimental design with a one-group pretest-posttest approach. A total of 17 women of reproductive age (20-35 years) in Malang, who were members of the Indonesian Midwives Association, participated in this program. The intervention consisted of face-to-face education sessions that combined lectures, discussions, and posters and videos. Participants' knowledge was measured before and after the intervention using a validated questionnaire. Data analysis was performed using descriptive statistics and the Wilcoxon signed-rank test. The results showed a statistically significant increase in participants' knowledge scores after the intervention (Z = -2.810$, p = 0.005). The average knowledge score increased from 94.12 (SD = 11.21) on the pre-test to 95.29 (SD = 11.72) on the post-test. All program outputs, including educational modules, media publications, and activity videos, were successfully completed. The interactive education model proved effective in increasing the knowledge of women of reproductive age about cardiovascular risks in pregnancy.
Comparing the Oncological Risk of Hormonal and Non-Hormonal Contraceptives in Cervical Cancer: A Literature Review Haifa Hasna Putri; Fiona Paramitha
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i1.523

Abstract

Cervical cancer is a malignancy with high morbidity and mortality rates among women worldwide, including Indonesia. While high-risk HPV (hr-HPV) infection is the primary cause, contraceptive use is strongly suspected to act as a significant cofactor in cervical carcinogenesis. This research aims to analyze the comparison of cervical cancer risk between hormonal and non-hormonal contraceptive use through a comprehensive literature review. The study design was a literature review with a systematic search strategy on PubMed and Google Scholar databases. Ten original research articles (5 national and 5 international journals) published between 2016 and 2026 were selected based on inclusion and exclusion criteria. The analysis results showed that 60% of the studies reported a significant association between long-term hormonal contraceptive use ≥ 5 years and an increased risk of cervical cancer, with Odds Ratio (OR) values ranging from 2.4 to 7.0. In contrast, non-hormonal contraceptive use, specifically the Intrauterine Device (IUD), consistently showed a lower risk profile or provided a protective effect against pre-cancerous lesions. However, some studies showed variations influenced by confounding factors such as age at first marriage and parity. Long-term hormonal contraceptive use is associated with an increased risk of cervical cancer, while non-hormonal contraceptives (IUD) have a better oncological safety profile. Comprehensive counseling and routine screening (VIA/Pap Smear) are required for contraceptive acceptors, especially long-term hormonal method users.
Co-Authors Erick Tanara Haifa Hasna Putri Halim, Alviannur Iman Rachmanto Rahmantio Adi Satrio Wibowo Tri Putra Rahmad Ramadani