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Zerlinda, Visca
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Uric acid levels as a predictor of cognitive function in the elderly Yuniati, Nilasari Indah; Zerlinda, Visca; Purwanti, Sugi
Science Midwifery Vol 13 No 3 (2025): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i3.2047

Abstract

This study aimed to examine the association between serum uric acid (SUA) levels and cognitive function among elderly individuals. An observational case-control study was conducted involving 37 elderly participants aged 60–75 years from As-Sakinah Elderly Integrated Health Post in Grendeng Sub-District, North Purwokerto, Indonesia. SUA levels were measured using a point-of-care testing (POCT) device, while cognitive function was assessed using the Montreal Cognitive Assessment–Indonesian version (MoCA-Ina). The mean SUA level was 5.52 ± 1.57 mg/dL, and the mean MoCA-Ina score was 19.05 ± 5.07, indicating that most participants demonstrated cognitive impairment. Pearson correlation revealed a non-significant negative association between SUA and cognitive scores (r = –0.225, p = 0.180). However, simple linear regression showed a significant inverse relationship (B = –0.214, p < 0.001), higher SUA levels were associated with lower cognitive performance. These findings suggest that while SUA may contribute to cognitive decline, it is not a standalone biomarker. Further longitudinal studies with larger samples are warranted to clarify its predictive value.
Co-Authors Sugi Purwanti Yuniati, Nilasari Indah