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Abbasi, Mohammad Amin
International Journal of Cardiovascular Practice
Medicine & Pharmacology

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Pulmonary Hypertension and Its Determinants in β-thalassemia Major and Intermedia Considering Left Ventricular Functional State Farahani, Behzad; Fadaii, Abbas; Khaheshi, Isa; Baktash, Forooz; Abbasi, Mohammad Amin; Mohammadi, Ronak; Paydary, Koosha
International Journal of Cardiovascular Practice Vol 1, No 1 (2016)
Publisher : International Journal of Cardiovascular Practice

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.68 KB) | DOI: 10.20286/ijcp-010107

Abstract

Introduction: Pulmonary hypertension (PHT) is a common complication in β-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with β thalassemia Major (TM) and β-thalassemia Intermedia (TI), considering left ventricular function.Methods: Pulmonary hypertension (PHT) is a common complication in β-thalassemia. We aimed to determine the prevalence of PHT and its main indicators in patients with β thalassemia Major (TM) and β-thalassemia Intermedia (TI), considering left ventricular function.Results: The overall prevalence of PHT in TM and TI group was estimated to be 35.2% and 29.3%, respectively; while reduced LVEF was evident in 22.7% and 10.1% of patients with TM and TI, respectively. No significant correlation was observed between mean PAP and LVEF in the patients with TI (Pearson coefficient = -0.096, P value = 0.345); while, an adverse association was revealed between mean PAP and LVEF in patients with TM (Pearson coefficient = -0.227, P value = 0.033). Upon univariate analysis, the only significant association was observed between LVEF and pulmonary hypertension among TM patients (P value = 0.001).Our results did not indicate that male gender and aging may affect the development of PHT.Conclusions: According to our findings, a considerable proportion of patients with TM and TI may have PHT. We detected an adverse association between mean PAP and LVEF in patients with TM. Left ventricular function was reduced in patients with PHT among TM group.
Effect of Nocturnal Oxygen Therapy on Electrocardiographic Changes Among Patients with Congestive Heart Failure Pishgahi, Mehdi; Bozorgmehr, Rama; Rastgari, Masoud; Abbasi, Mohammad Amin
International Journal of Cardiovascular Practice Vol 1, No 2 (2016)
Publisher : International Journal of Cardiovascular Practice

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.878 KB) | DOI: 10.20286/ijcp-010204

Abstract

Introduction: Nocturnal hypoxia is an important factor in increasing the risk of mortality in patients with chronic heart failure and is associated with atrial and ventricular arrhythmias. In addition, QT dispersion (QTd) is used as a prognostic sign in determining future malignant arrhythmias and sudden cardiac death. In the current study, we investigated the effect of nocturnal oxygen therapy (NOT) on electrocardiographic changes among patients with chronic heart failure.Methods: In this study, a consecutive of 154 patients (87 males and 67 females) known with chronic heart failure (EF ≤ 40%) were enrolled. The patients were administered NOT (oxygen flow of 2 L/min for 8 hours during sleeping). Electrocardiography was takenbefore and after the NOT, and RR interval, PR interval and QTd were measured each time.Results: The mean age of the participants was 61.3 ± 11.4 years. Our results revealed significant reduction in QTd (55.8 ± 7.5 vs. 61.4± 9.1 msec, P = 0.001) and heart rate (79.6 ± 4.7 vs. 76.8 ± 4.3, P = 0.001) in a patient’s electrocardiogram after NOT.Conclusions: In this study, NOT decreased heart rate and QTd in patients with chronic heart failure, but not PR interval, which could consequently decrease the risk of malignant arrhythmias and sudden cardiac death.
Co-Authors Baktash, Forooz Bozorgmehr, Rama Fadaii, Abbas Farahani, Behzad Khaheshi, Isa Mohammadi, Ronak Paydary, Koosha Pishgahi, Mehdi Rastgari, Masoud