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All Journal BAREKENG: Jurnal Ilmu Matematika dan Terapan Canrea Journal: Food Technology, Nutritions, and Culinary Journal
Zainuddin, Zaraswati Dwyana
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Agriculture, Biological Sciences & Forestry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Energy Engineering Mathematics Mechanical Engineering Physics Transportation

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AVERAGE LINKAGE CLUSTERING METHOD AND MOLECULAR DOCKING STUDY ON DATE PALM (PHOENIX DACTYLIFERA L.) AS POTENTIAL ANTI-ANEMIA AGENT Siswanto, Siswanto; Rasyid, Herlina; Ramadhani, Nur Aliah; Caesar, Nadia Nazwadiah; Sunusi, Nurtiti; Zainuddin, Zaraswati Dwyana
BAREKENG: Jurnal Ilmu Matematika dan Terapan Vol 18 No 4 (2024): BAREKENG: Journal of Mathematics and Its Application
Publisher : PATTIMURA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/barekengvol18iss4pp2459-2470

Abstract

Anemia, characterized by blood hemoglobin (Hb) levels below the World Health Organization's (WHO) normal limit, remains a significant health concern. Date fruit (Phoenix dactylifera L.) stands out as an herbal plant boasting the highest iron content at 13.7 mg, suggesting its potential as an anti-anemia agent. This study aimed to explore the anti-anemia potential of active compounds in date fruit using average linkage clustering and validated using molecular docking. Compounds from dates were gathered via GC-MS analysis and online databases, totaling 145 compounds—50 from GC-MS and 95 from Knapsack and Dr. Duke databases. Additionally, 5 lead compounds served as positive controls for comparison. SwissADME online servers assessed the compounds' properties, serving as materials for the clustering method. The average linkage clustering method was employed, yielding an excellent dendrogram with a cophenetic correlation of 0.711. Notably, a total of 17 date fruit compounds are in the same cluster as the lead compounds. Molecular docking revealed 4 date palm fruit-derived compounds as potential PHD enzyme inhibitors, promising for anemia treatment. In conclusion, the average linkage clustering method and validation using molecular docking approaches highlight date fruit's potential as an alternative anemia treatment, showcasing the significance of interdisciplinary methodologies in drug discovery.
Development of freeze-dried lactic acid bacteria starter for coffee fermentation: Optimizing incubation time and coating formulation Tawali, Abu Bakar; Amelia, Vemy; Zainuddin, Zaraswati Dwyana; Zainal, Zainal; Nur, Nadiah; Mahendradatta, Meta; Fitri, Fitri; Ramli, Andi Rahmayanti
jurnal1 VOLUME 8 ISSUE 2, DECEMBER 2025
Publisher : Hasanuddin University Food Science and Technology Study Program

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/canrea.v8i2.1928

Abstract

This study aimed to develop a freeze-dried lactic acid bacteria (LAB) starter for coffee fermentation by optimizing incubation time and coating formulation. The research was conducted in two stages: determining the optimal incubation time for the liquid coffee starter and formulating the dry starter coating material. The liquid starter was prepared using coffee skin powder, glucose, peptone, and minerals, and inoculated with Lactobacillus plantarum, Weissella sp., and Leuconostoc mesenteroides. Incubation was performed at room temperature for 24, 28, 32, and 36 h. The optimal incubation time was found to be 32 h, resulting in a LAB viability of 4.2x1013 CFU/mL and a total acid content of 1.76%. The dry starter was prepared by encapsulating the liquid starter with various coating materials (gelatin and gum arabic) at different concentrations (5, 6, and 7%) using the freeze-drying method. The formulation with 5% gum arabic best maintained cell viability at 46.77% over a 4-week storage period. Coffee fermentation using the dry starter showed improved organoleptic qualities, with the best results obtained after 48 h of fermentation. This study presents a sustainable approach to producing high-quality fermented coffee, such as Luwak coffee, without the use of animals.
Co-Authors Abu Bakar Tawali Amelia, Vemy Caesar, Nadia Nazwadiah Fitri Fitri Meta Mahendradatta Nur, Nadiah NURTITI SUNUSI Ramadhani, Nur Aliah Ramli, Andi Rahmayanti Rasyid, Herlina S Siswanto Zainal Zainal