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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Cermin Dunia Kedokteran
Dzikri, Dykall Naf'an
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Health Professions Immunology & microbiology Public Health

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Penyembuhan Luka Tanpa Bekas: Kemajuan dan Inovasi Terkini Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Agustus 2025
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1678

Abstract

Scarless wound healing, a hallmark of mid-gestation fetal skin, is characterized by minimal inflammation, balanced transforming growth factor-β isoforms, and a provisional extracellular matrix rich in type III collagen and hyaluronan. Decades of mechanistic studies have mapped how these features collectively enable rapid, regenerative closure without fibrosis. Contemporary adult-tissue strategies therefore focus on recapitulating the fetal milieu through targeted cytokine modulation, notably down-regulating TGF-β1/β2 while supplementing antifibrotic TGF-β3. Mesenchymal stem cells (MSCs) and their secretome have emerged as potent immunomodulators and angiogenic stimulants that steer wounds toward regeneration rather than scarring. Genetic engineering, biomaterial scaffolds, and extracellular-vesicle delivery platforms further enhance MSC persistence, homing, and paracrine potency. Parallel advances in bio-inspired hydrogels, microneedle arrays, and nanofiber dressings provide spatiotemporal release of growth factors, antimicrobial agents, and oxygen to orchestrate orderly repair. Such combinatorial nanotechnologies not only accelerate re-epithelialization but also limit hypertrophic collagen deposition, leading to flatter, more elastic neodermis.
The Effectiveness of Sexual Transmitted Disease Education among Healthcare Workers and Non-Healthcare Workers Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an; Wahidah, Wahidah
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.203-208

Abstract

Background: Sexually transmitted diseases (STDs) remain a significant global health concern. Education plays a crucial role in prevention, but its effectiveness may vary among different groups. Purpose: The purpose of this research was to determine how well both medical and non-medical staff at Dharma Wanita Orthopaedic Hospital Soeharso Surakarta understood sexually transmitted diseases, as measured by the STD-KQ questionnaire. Methods: This research employed a cross-sectional analytic observational design, involving 46 participants. Data were gathered through a sequence of pre-intervention assessment, educational program, and post-intervention evaluation. Statistical analysis was performed using paired t-tests and independent t-tests. Results: Prior to the intervention, healthcare workers possessed a significantly greater understanding of the subject matter (p=0.022). Both groups exhibited substantial improvements in their knowledge after participating in the educational program (p<0.05). The average scores for healthcare workers improved from 8.19 (± 4.80) to 16.15 (± 4.70), a statistically significant increase (p=0.001). Similarly, non-healthcare workers' scores rose from 13.40 (± 5.92) to 18.10 (± 4.24) (p=0.013). After the intervention, the initial difference in knowledge between the two groups was no longer statistically significant (p=0.154), indicating a closing of the knowledge gap. Conclusion: The educational intervention effectively improved STD knowledge in both groups and reduced the knowledge disparity between HCWs and NHCWs. The research points out the need for thorough and accessible sexual health instruction to improve STD understanding within diverse populations.
Kusta Multibasiler dengan Reaksi Tipe 2 pada Dewasa Muda: Laporan Kasus: Laporan Kasus Prakoeswa, Flora Ramona Sigit; Islamuddin, Tri Kurnia Ahmad; Dzikri, Dykall Naf'an; Pramuningtyas, Ratih
Cermin Dunia Kedokteran Vol 52 No 12 (2025): Desember 2025
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i12.1573

Abstract

Introduction: Leprosy or Hansen’s disease, is a chronic granulomatous infection caused by Mycobacterium leprae, which affects the skin and peripheral nerves. The disease occurs more frequently in males and remains a significant public health issue in endemic countries such as Indonesia. Case: A 23-year-old male presented with swelling of both hands, feet, and ears, accompanied by numbness and radiating pain. Dermatological examination revealed multiple erythematous papules and nodules that were anesthetic and symmetrically distributed, accompanied by onychodystrophy. Enlargement of the auricularis magnus and posterior tibial nerves was observed, as well as sensory disturbance in the ulnar nerve area. Slit-skin smear examination of the left ear showed acid-fast bacilli (2+ bacilli per field of view). Discussion: The patient was diagnosed with multibacillary-type leprosy with a type 2 reaction (erythema nodosum leprosum). This reaction represents a complex immune response that can lead to permanent nerve damage if not promptly managed. Conclusion: Comprehensive management involving a combination of anti-leprosy drugs, corticosteroids, analgesics, vitamin B complex, and medical rehabilitation is essential to prevent disability progression and improve functional outcomes. Patient education and regular follow-up are crucial for treatment success. The main challenge in this case is to prevent disability progression and maximize remaining function through comprehensive rehabilitation.
Hubungan Pola Makan dan Kualitas Penggunaan Sunscreen SPF ≥ 30 dengan Kejadian Acne Vulgaris pada Mahasiswa Generasi Z: Penelitian Prakoeswa, Flora Ramona Sigit; Fatimah, Lina Nur; Dzikri, Dykall Naf'an; Sutrisna, Em; Fithriyah, Sa’idatul
Cermin Dunia Kedokteran Vol 53 No 07 (2026): Juli 2026 - CDK 355
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i07.1838

Abstract

Introduction: Acne vulgaris (AV) is an inflammatory disorder of the pilosebaceous follicles that commonly affects adolescents and young adults. AV is influenced by multiple factors, including diet and the use of cosmetic products such as sunscreen. This study aimed to analyze the association of dietary patterns and the quality of SPF ≥ 30 sunscreen use with AV among Generation Z university students. Methods: This analytical observational study used a cross-sectional design and included 108 eligible respondents. Data were collected using questionnaires on dietary patterns and quality of sunscreen use, as well as a clinical examination for AV. Bivariate analysis was performed using Fisher’s exact test. Results: Dietary patterns among Generation Z were not significantly associated with the presence of acne vulgaris (p = 0.609). The quality of SPF ≥ 30 sunscreen use was also not significantly associated with the incidence of acne vulgaris (p = 0.441). Conclusion: Neither dietary patterns nor the quality of SPF ≥ 30 sunscreen use showed a statistically significant association with the incidence of acne vulgaris in the study sample. Further studies with larger populations and multivariable analyses are needed to evaluate other potential confounding factors.
Association of Air Pollution Exposure and Face-Washing Behavior with Acne Vulgaris Among Medical Students: Research Prakoeswa, Flora Ramona Sigit; Permatasari, Nasya; Dzikri, Dykall Naf'an; Pramuningtyas, Ratih; Kurniati, Yuni Prastyo
Cermin Dunia Kedokteran Vol 53 No 10 (2026): Oktober 2026 - CDK 357
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i10.1837

Abstract

Introduction: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit that is common among young adults. Air pollution exposure and face-washing behavior may be associated with AV. This study aimed to analyze the association of air pollution exposure and face-washing behavior with AV among medical students. Methods: This analytical cross-sectional study included 117 eligible students from the 2024 cohort of the Faculty of Medicine, Universitas Muhammadiyah Surakarta, using total sampling. Data were collected using questionnaires that underwent content and face validation, as well as clinical observation. We assessed the association between facewashing behavior and AV using the Chi-square test, and the association between air pollution exposure and AV using Fisher's exact test. Results: AV prevalence was 79.5%. Overall, 94.9% of respondents had heavy air pollution exposure, and 59.8% had positive face-washing behavior. Face-washing behavior was not significantly associated with AV (Chi-square = 1.521; p = 0.217; OR for negative vs positive behavior = 1.83; 95% CI 0.69–4.84). Air pollution exposure was also not significantly associated with AV (Fisher's exact p = 0.601; OR for heavy vs moderate exposure = 2.02; 95% CI 0.35–11.76). Conclusion: In this sample, neither air pollution exposure nor face-washing behavior was significantly associated with AV. Interpretation is limited by the highly imbalanced exposure distribution, the small moderate-exposure group, and the cross-sectional design.
Efficacy of Doxycycline Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections Among People with or Without HIV: A Systematic Review and Meta-Analysis of Randomized Controlled Trials: Systematic Review Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an; Anggita, Vinka Dwi
Cermin Dunia Kedokteran Vol 53 No 09 (2026): September 2026 - CDK 356
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i09.2210

Abstract

Introduction: Bacterial sexually transmitted infections (STIs) remain a significant burden among populations at high risk, including people living with HIV (PLWH) and HIV-negative individuals receiving HIV pre-exposure prophylaxis (PrEP). This study evaluated the efficacy and safety of doxycycline pre- and post-exposure prophylaxis for preventing bacterial STIs among people with or without HIV. Methods: This systematic review followed PRISMA 2020 guidelines and was prospectively registered in PROSPERO (CRD420251171815). We conducted comprehensive searches in PubMed, Embase, and Cochrane CENTRAL through October 2025. We included randomized controlled trials evaluating doxycycline prophylaxis versus standard care. Meta-analysis was performed using random-effects models in RevMan 5.4. Results: Seven randomized controlled trials (2,091 participants) were included. Doxycycline prophylaxis significantly reduced bacterial STI incidence by 57% (pooled RR 0.43, 95% CI 0.35–0.53; p < 0.00001; I² = 42%). In the subgroup analysis of HIV-positive participants, doxycycline achieved a 62% reduction (RR 0.38; 95% CI 0.28–0.52). Pathogen-specific analysis showed a 72% reduction for chlamydia (RR 0.28), a 72% reduction for syphilis (RR 0.28), and a 44% reduction for gonorrhea (RR 0.56). Safety outcomes were summarized descriptively, with gastrointestinal symptoms most frequently reported; no pooled adverse-event or discontinuation estimate was calculated. The number needed to treat calculated from pooled event counts was approximately 4. Conclusion: Doxycycline prophylaxis reduced bacterial STI incidence in high-risk populations with and without HIV. These findings support considering doxycycline prophylaxis as a prevention strategy, while emphasizing limitations in regimen-specific evidence and the need for ongoing safety and antimicrobial-resistance monitoring.
Effects of Hypoxic Adipose-Derived Mesenchymal Stem Cells and Their Secretome on Type II Collagen Expression in a Rabbit Model of Disc Degeneration: Research Dzikri, Dykall Naf'an; Romaniyanto, Romaniyanto; Dzikri, Dykall; Sadewa, Daffa; Fachreza, Muhammad Setya
Cermin Dunia Kedokteran Vol 53 No 10 (2026): Oktober 2026 - CDK 357
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i10.2354

Abstract

Introduction: Intervertebral disc (IVD) degeneration is a major cause of low back pain, and is characterized by the loss of extracellular matrix, particularly type II collagen. Regenerative therapies using mesenchymal stem cells (MSCs) and their secretome have shown promise, but their comparative effects on type II collagen expression require further investigation. This study aimed to evaluate and compare the effects of allogeneic hypoxic adipose-derived mesenchymal stem cells (Ad-MSCs) and their secretome on type II collagen expression in a rabbit model of IVD degeneration. Methods: A true experimental study was conducted on 18 New Zealand White rabbits. Degeneration was induced by needle puncture. Subjects were divided into three groups: control (fibrin glue), P1 (hypoxic Ad-MSC), and P2 (secretome). After 8 weeks, type II collagen expression was analyzed using immunohistochemistry. Results: Both P1 and P2 showed significantly higher type II collagen expression than the control (p = 0.001 and p < 0.001, respectively). The secretome group (P2) showed significantly higher expression than the Ad-MSC group (P1) (p = 0.039). These findings suggest that the secretome may provide a greater stimulatory effect on type II collagen expression than direct cell administration. Conclusion: The hypoxic Ad-MSC-derived secretome resulted in higher type II collagen expression than hypoxic Ad-MSCs administration in this rabbit model.
Co-Authors Anggita, Vinka Dwi Dzikri, Dykall Em Sutrisna Fachreza, Muhammad Setya FATIMAH, Lina Nur Fithriyah, Sa’idatul Flora Ramona Sigit Prakoeswa Islamuddin, Tri Kurnia Ahmad Permatasari, Nasya Ratih Pramuningtyas Romaniyanto, Romaniyanto Sadewa, Daffa Wahidah Wahidah Yuni Prastyo Kurniati