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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Cermin Dunia Kedokteran
Dzikri, Dykall Naf'an
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Health Professions Immunology & microbiology Public Health

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Penyembuhan Luka Tanpa Bekas: Kemajuan dan Inovasi Terkini Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an
Cermin Dunia Kedokteran Vol 52 No 8 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i8.1678

Abstract

Scarless wound healing, a hallmark of mid-gestation fetal skin, is characterized by minimal inflammation, balanced transforming growth factor-β isoforms, and a provisional extracellular matrix rich in type III collagen and hyaluronan. Decades of mechanistic studies have mapped how these features collectively enable rapid, regenerative closure without fibrosis. Contemporary adult-tissue strategies therefore focus on recapitulating the fetal milieu through targeted cytokine modulation, notably down-regulating TGF-β1/β2 while supplementing antifibrotic TGF-β3. Mesenchymal stem cells (MSCs) and their secretome have emerged as potent immunomodulators and angiogenic stimulants that steer wounds toward regeneration rather than scarring. Genetic engineering, biomaterial scaffolds, and extracellular-vesicle delivery platforms further enhance MSC persistence, homing, and paracrine potency. Parallel advances in bio-inspired hydrogels, microneedle arrays, and nanofiber dressings provide spatiotemporal release of growth factors, antimicrobial agents, and oxygen to orchestrate orderly repair. Such combinatorial nanotechnologies not only accelerate re-epithelialization but also limit hypertrophic collagen deposition, leading to flatter, more elastic neodermis.
The Effectiveness of Sexual Transmitted Disease Education among Healthcare Workers and Non-Healthcare Workers Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an; Wahidah, Wahidah
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.203-208

Abstract

Background: Sexually transmitted diseases (STDs) remain a significant global health concern. Education plays a crucial role in prevention, but its effectiveness may vary among different groups. Purpose: The purpose of this research was to determine how well both medical and non-medical staff at Dharma Wanita Orthopaedic Hospital Soeharso Surakarta understood sexually transmitted diseases, as measured by the STD-KQ questionnaire. Methods: This research employed a cross-sectional analytic observational design, involving 46 participants. Data were gathered through a sequence of pre-intervention assessment, educational program, and post-intervention evaluation. Statistical analysis was performed using paired t-tests and independent t-tests. Results: Prior to the intervention, healthcare workers possessed a significantly greater understanding of the subject matter (p=0.022). Both groups exhibited substantial improvements in their knowledge after participating in the educational program (p<0.05). The average scores for healthcare workers improved from 8.19 (± 4.80) to 16.15 (± 4.70), a statistically significant increase (p=0.001). Similarly, non-healthcare workers' scores rose from 13.40 (± 5.92) to 18.10 (± 4.24) (p=0.013). After the intervention, the initial difference in knowledge between the two groups was no longer statistically significant (p=0.154), indicating a closing of the knowledge gap. Conclusion: The educational intervention effectively improved STD knowledge in both groups and reduced the knowledge disparity between HCWs and NHCWs. The research points out the need for thorough and accessible sexual health instruction to improve STD understanding within diverse populations.
Kusta Multibasiler dengan Reaksi Tipe 2 pada Dewasa Muda: Laporan Kasus: Laporan Kasus Prakoeswa, Flora Ramona Sigit; Islamuddin, Tri Kurnia Ahmad; Dzikri, Dykall Naf'an; Pramuningtyas, Ratih
Cermin Dunia Kedokteran Vol 52 No 12 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i12.1573

Abstract

Introduction: Leprosy or Hansen’s disease, is a chronic granulomatous infection caused by Mycobacterium leprae, which affects the skin and peripheral nerves. The disease occurs more frequently in males and remains a significant public health issue in endemic countries such as Indonesia. Case: A 23-year-old male presented with swelling of both hands, feet, and ears, accompanied by numbness and radiating pain. Dermatological examination revealed multiple erythematous papules and nodules that were anesthetic and symmetrically distributed, accompanied by onychodystrophy. Enlargement of the auricularis magnus and posterior tibial nerves was observed, as well as sensory disturbance in the ulnar nerve area. Slit-skin smear examination of the left ear showed acid-fast bacilli (2+ bacilli per field of view). Discussion: The patient was diagnosed with multibacillary-type leprosy with a type 2 reaction (erythema nodosum leprosum). This reaction represents a complex immune response that can lead to permanent nerve damage if not promptly managed. Conclusion: Comprehensive management involving a combination of anti-leprosy drugs, corticosteroids, analgesics, vitamin B complex, and medical rehabilitation is essential to prevent disability progression and improve functional outcomes. Patient education and regular follow-up are crucial for treatment success. The main challenge in this case is to prevent disability progression and maximize remaining function through comprehensive rehabilitation.
Co-Authors Flora Ramona Sigit Prakoeswa Islamuddin, Tri Kurnia Ahmad Ratih Pramuningtyas Wahidah Wahidah