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All Journal Asian Australasian Neuro and Health Science Journal (AANHS-J) MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation
Abdurrahman Mousa Arsyad
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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ANALYSIS OF GCS AS A PREDICTOR OF MIDLINE SHIFT ON NCCT SCAN IN PATIENTS WITH ACUTE TRAUMATIC SUBDURAL HEMATOMA Budiman; Evo Elidar Harahap; Abdurrahman Mousa Arsyad
MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Vol. 6 No. 2 (2025): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v6i2.212

Abstract

The Glasgow Coma Scale (GCS) is commonly used to assess the severity of head trauma; however, it is not sufficiently accurate for predicting midline shift (MLS) without imaging support. This study aims to analyze the sensitivity and specificity of GCS in predicting MLS in patients with acute SDH. Subjects were patients diagnosed with acute traumatic SDH who underwent non-contrast head CT scans. Data were collected to assess the correlation between GCS scores and MLS values and to determine the GCS cut-off point for predicting MLS. Among 34 patients, the majority were male (76.5%) and aged between 18–34 years (35.3%). Most patients had a GCS score of 9–13 (38.2%) and showed subarachnoid hemorrhage on CT scan (44.1%). A strong correlation was found between lower GCS scores and increased MLS. The mean MLS increased significantly with decreasing levels of consciousness. The GCS cut-off score to differentiate significant MLS was 13, with a sensitivity of 100%, specificity of 79.3%, positive predictive value of 87%, and negative predictive value of 85%. GCS has a strong correlation with MLS and can be used as a reliable clinical indicator to predict MLS in patients with acute traumatic SDH.
Comparative Analysis of Matrix Metalloproteinase-9 and Estrogen Receptor Expression in Intradural Extramedullary Meningioma and Their Association with Postoperative Outcomes: A 2020–2025 Study at H. Adam Malik Hospital Ahmad Rafiqi; Sabri Ibrahim; Abdurrahman Mousa Arsyad
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 8 No. 02 (2026): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhs-j.v8i02.27270

Abstract

This study analyzes the association between the expression of Matrix Metalloproteinase-9 (MMP-9) and Estrogen Receptor (ER) biomarkers in intradural extramedullary (IDEM) spinal meningioma tissue and neurological deficit recovery, clinical outcomes, and postoperative complications. An observational analytic cross-sectional study was conducted on 20 patients following IDEM spinal meningioma resection at H. Adam Malik General Hospital Medan from 2020 to 2025. Biomarker expression was evaluated using immunohistochemistry, while clinical outcomes were assessed using the modified Rankin Scale (mRS) and statistically analyzed. The majority of patients were female (80%), with the thoracic region being the most frequent tumor location (75%). MMP-9 and ER expression showed a very strong negative correlation with neurological deficit recovery (r = -0.815 and r = -0.806; p < 0.001). The improved patient group exhibited significantly lower median MMP-9 and ER scores (p < 0.001). High MMP-9 expression and positive ER status were also significantly associated with an increased incidence of postoperative complications (OR = 6.00; p < 0.001). High MMP-9 expression and positive ER status in IDEM spinal meningioma tissue are associated with minimal neurological recovery, poorer clinical outcomes, and a higher risk of postoperative complications. Both biomarkers hold potential as prognostic predictors for patient risk stratification.
Co-Authors Ahmad Rafiqi Budiman Evo Elidar Harahap Sabri Ibrahim