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All Journal Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy
Febriani, Rizkina Elistya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Kejadian Drug-Related Problems Pada Pasien Rawat Inap dengan Diabetes Melitus Berdasarkan Kriteria PCNE : Literatur Review Febriani, Rizkina Elistya; Karuniawati, Hidayah; Rahman, Anees Ur
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.956

Abstract

Non-communicable chronic diseases such as diabetes mellitus (DM) are a significant health burden worldwide. In the treatment of DM patients, long-term drug use is inevitable and increases the risk of Drug-Related Problems (DRPs). The presence of DRPs can affect the effectiveness of therapy and the risk of side effects in hospitalized DM patients. This review aims to evaluate various studies conducted on DRPs in hospitalized DM patients based on the Pharmaceutical Care Network Europe (PCNE) classification. A systematic search of relevant articles in the last 10 years through the SpringerLink, ScienceDirect, Scopus, and PubMed databases. Irrelevant studies, review articles, and no data on DRP classification using PCNE or outpatients will be excluded. The review found four articles discussing DRP classification using PCNE in hospitalized DM patients. The number of DRPs varied, ranging from 253 to 873 cases. The proportion of patients experiencing at least one DRP was also relatively high, ranging from 48.1% to 84.5%. The most common problem was treatment ineffectiveness (P1.2), which accounted for more than half of the DRPs in the three studies reviewed, namely 62.0%, 79.6%, and 52.7%. The most common cause of DRPs came from the patient-related domain (C7.1) at 71.85%. Other domains that caused DRPs were the Drug use domain (C6.1) at 62.0%, other domains (C9) at 40.9%, the drug selection domain (C1.6) at 26%, and the dose selection domain (C3.5) at 25.9%. The occurrence of DRPs is a significant problem in the management of diabetes mellitus, especially in the hospital environment. The ineffectiveness of therapy is the main problem of DRPs. The high number of DRPs from other domains indicates that many causes of DRPs are not classified explicitly in the PCNE category.
AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) DAN PERASAN JERUK NIPIS (Citrus aurantifolia) TERHADAP BAKTERI Escherichia coli dan Shigella flexneri Febriani, Rizkina Elistya; Munawaroh, Rima
Usadha Journal of Pharmacy Vol. 1 No. 4 (2022): November
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v1i4.134

Abstract

Infeksi termasuk dalam masalah kesehatan yang umum di negara maju ataupun negara berkembang seperti di Indonesia karena jumlah penyakit dan kematian yang relatif tinggi. Bakteri merupakan penyebab utama infeksi, bakteri dibedakan menjadi bakteri gram positif dan gram negatif, salah satu bakteri gram negatif yaitu bakteri Escherichia coli dan Shigella flexneri. Daun sirih merah dan jeruk nipis diketahui memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk melihat potensi kombinasi kedua ekstrak tanaman tersebut sebagai agen antibakteri pada bakteri Escherichia coli dan Shigella flexneri. Daun sirih merah diekstraksi secara maserasi menggunakan etanol 96% sedangkan buah jeruk nipis diperas dan diuji aktivitas antibakterinya terhadap bakteri Escherichia coli dan Shigella flexneri dengan loading ekstrak 10, 5, 2,5, dan 1,25 mg/disk. Antibiotik ciprofloxacin digunakan sebagai kontrol positif dan DMSO 100% digunakan sebagai kontrol negatif. Ekstrak daun sirih merah dan perasan jeruk nipis dapat menghambat kedua bakteri tersebut. Kombinasi ekstrak daun sirih merah dan ekstrak perasan jeruk nipis dengan perbandingan konsentrasi 5: 1,25, 2,5:2,5, dan 1,25:5 mg/disk menghasilkan diameter zona hambat terhadap bakteri Escherichia coli dan Shigella flexneri lebih kecil dibandingkan dengan penambahan uji ekstrak tunggal. Hasil KLT Bioautografi menunjukkan senyawa aktif dalam sirih merah adalah flavonoid dan flavonol sedangkan yang dari jeruk nipis adalah flavonoid dan flavonol.
Co-Authors Hidayah Karuniawati Rahman, Anees Ur Rima Munawaroh