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All Journal IJRETINA - International Journal of Retina
Özkaya, Dilek
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Health Professions Medicine & Pharmacology Public Health

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PROTECTIVE EFFECTS OF SELENIUM SUPPLEMENTATION AGAINST HIGH FRUCTOSE CORN SYRUP-INDUCED RETINAL DAMAGE IN RATS THROUGH REDUCTION OF INFLAMMATION AND APOPTOSIS Usta, Gulsah; Savran, Mehtap; Özkaya, Dilek; Karaca, Umut; Karakuyu, Nasıf Fatih
International Journal of Retina Vol 8 No 2 (2025): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2025.vol008.iss002.301

Abstract

Introduction: High fructose corn syrup (HFCS) consumption is associated with metabolic complications, including retinopathy. The aim of the current study is to investigate the potential protective effect of selenium (Se) against HFCS-induced retinal damage. Methods: Forty Wistar albino rats were divided into four groups (n=7 each): (I) control; (II) high fructose corn syrup (HFCS, 20% in diet); (III) HFCS + Se (20% in diet, 0.3 mg/kg orally); (IV) Se only. Retinal damage was assessed using histopathological (retinal thickness) and immunohistochemical (TNF-α, and Cas-3 expression) analysis. Results: Retinal thickness measurements revealed a significant increase in the HFCS group compared to the Control group, HFCS+Se group and Se group (all group, p<0.0001). Immunohistochemical analysis showed increased TNF-α expression in the HFCS group compared to the Control and Se groups (p<0.01), with a non-significant decrease in the HFCS+Se group (p > 0.05). Cas-3 expression was significantly increased in the HFCS group compared to the Control, Se groups (p<0.001 for both) and HFCS+Se group (p<0.01). Conclusion: Se supplementation partially protects against HFCS-induced retinal damage, particularly by reducing inflammation and apoptosis.
Co-Authors Karaca, Umut Karakuyu, Nasıf Fatih Savran, Mehtap Usta, Gulsah