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All Journal Jurnal Periodic Jurusan Kimia UNP Jambura Journal of Chemistry
Rahmayani, Sherly
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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Uji Aktivitas Antikolesterol Chromolaena Odorata Secara In Silico dengan Sisi Penghambat HMG-CoA Reduktase Irma, Tri Wahyuni; Amelia, Fitri; Rahmayani, Sherly
Periodic Vol 14, No 2 (2025): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v14i2.132836

Abstract

Cholesterol is a disease caused by an unhealthy lifestyle. Cholesterol occurs because fat accumulates in blood vessels so that plaques form which causes blood vessels to narrow. With this problem in mind, this research was conducted to predict drug compounds capable of treating cholesterol disease by comparing them with simvastatin. Chromolaena odorata can be used as a medicinal plant that can treat cholesterol disease because this plant contains active compounds of flavonoids. This research tries to see the active interaction with HMG-CoA reductase inhibition in an improved way using Moe 2009.10 software. Based on the results of research that has been done based on the comparison of ∆G, compound O-Geranylvanillin, Avenestergenin B2, 5-O-Methylembelin, Kaempferol 3-[2’’-(6’’’-coumaroylglucosyl)- rhamnoside] 7-glucoside, ( ± )-Taxifolin, Hesperetin, ( ± )-Naringenin, Luteolin, 3′ ,4′ -Methylenedioxy epicatechin 5,7-dimethyl ether has the potential to be used as a candidate for anti-cholesterol drugs to replace simvastatin through the HMG-CoA reductase inhibition mechanism.
Studi In Silico pada Ekstrak Buah Andaliman (Zanthoxylum acanthopodium DC.) Menghambat α-Amylase sebagai Antidiabetes Rani, Rada; Amelia, Fitri; Rahmayani, Sherly
Periodic Vol 14, No 2 (2025): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v14i2.132859

Abstract

DM is a metabolic disorder characterized by chronic high blood glucose levels that can cause death. Long-term hyperglycemia can slowly cause retinopathy, heart and blood vessel disease, and neuropathy. Andaliman is known to be used as an anti-diabetic because it contains flavonoids, terpenes, and essential oils that are effective in lowering blood glucose levels. This study aims to test the potential for inhibition of the α-amylase enzyme using the molecular docking method. The study was conducted by utilizing a protein that has PDB ID 2QV4 to interact with active compounds in the ethanol extract of andaliman fruit. The results obtained were that the compounds astragalin, cyclocerine, coribulbine, Kaempferol-3-glucuronide, morin, mururin A, oroxin B, rhamnetin, and pyrocyanidin B7 have good binding ability to α-amylase. Thus, these compounds have the potential as antidiabetics.
Studi In Silico pada Ekstrak Daun Sirsak (Annona muricata Linn.) Menghambat α-Amylase dan α-Glukosidase sebagai Antidiabetes Ramadhani, Andini Novita; Amelia, Fitri; Rahmayani, Sherly
Jambura Journal of Chemistry Vol 7, No 2 (2025): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i2.24224

Abstract

Diabetes melitus (DM) merupakan kelainan metabolisme glukosa yang ditandai dengan gangguan sekresi dan resistensi insulin. Diabetes melitus tipe 2 (DMT2) dan komplikasinya merupakan penyakit tidak menular dengan angka kematian yang tinggi. Daun A. muricata dapat digunakan sebagai antidiabetes tipe 2. Daun sirsak mengandung senyawa aktif berupa senyawa alkaloid, karbohidrat, saponin, protein dan asam amino, fitosteroid, kumarin, quinon, minyak dan lemak, serta fenolik dan flavonoid yang dapat menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk menghambat α-Amylase dan α-Glukosidase. Untuk mengetahui aktivitas penghambatannya, dilakukan molekuler docking menggunakan protein dengan PDB ID : 3BAJ dan PDB ID : 5NN5 yang akan diinteraksikan dengan senyawa aktif yang terkandung dalam ekstrak metanol daun sirsak. Senyawa Octadecanoic acid dan Eicosanoic acid mempunyai afinitas pengikatan yang baik terhadap α-amilase. Sedangkan pada α-Glukosidase senyawa yang mempunyai afinitas pengikatan paling baik adalah n-Hexadecanoic acid. Senyawa asam n-Hexadecanoic acid berpotensi untuk dikembangkan sebagai antidiabetes.
Co-Authors Fitri Amelia Irma, Tri Wahyuni Ramadhani, Andini Novita Rani, Rada