Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Journal of Medical Biomedical and Applied Sciences
El-Hanbally, Saber
Journal of Medical Biomedical and Applied Sciences
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Bio-equivalence Study of Two Oral Flumequine Formulations (Flumisol® and Maquin®) in Broiler Chickens El-Hanbally, Saber
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.689 KB) | DOI: 10.15520/jmbas.v3i12.168

Abstract

The present study was designed to assess the comparative bio-equivalence of Flumisol®and Maquin® in healthybroiler chickens after oral administration of both products in a dose of 12 mg flumequine /kg.b.wt. Twenty four broilerchickens were divided equally into two groups (12 chickens for each group). The first group was designed to study thepharmacokinetics of Flumisol®, while the 2nd group was designed to study the pharmacokinetics of Maquin®. Eachbroiler chicken in both groups was orally administered with 12 mg flumequine /kg b.wt. Blood samples were obtainedfrom the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours aftera single oral administration. The disposition kinetics of Flumisol® and Maquin® following oral administration of 12 mgflumequine/kg b.wt, revealed that the maximum blood concentration [Cmax] were 1.88 and 1.76 g/ml, attained at [tmax]of 1.42 and 1.41 hours, respectively.In conclusion: Maquin® is bioequivalent to Flumisol® since the ratios of Cmax, AUC0􀀀24 and AUC0􀀀1 (T/R) were0.93, 0.89 and 0.88, respectively. These are within the Bio-equivalence acceptance range. Flumisol® and Maquin®are therefore bioequivalent and interchangeable.
Co-Authors