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All Journal SCIENTIA JOURNAL Eduvest - Journal of Universal Studies
Gilbert Lister
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Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Test of Effectiveness of Beet Tuber Extract (Beta Vulgaris) Extract On Cholesterol Levels and Kidney Histopathology In Aloxan-Induced Diabetic Rats Jesika, Jesika; Angie, Evelyn; Gilbert Lister
Eduvest - Journal of Universal Studies Vol. 5 No. 9 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i9.52222

Abstract

Objective: To evaluate the effectiveness of beetroot extract on total cholesterol levels and kidney histopathology in alloxan-induced diabetic white rats (Rattus norvegicus).Methods: This experimental study used a post-test only control group design with 24 male rats divided into six groups: normal, negative control (alloxan + aquadest), positive control (alloxan + metformin), and three treatment groups receiving beetroot extract at doses of 22.5 mg/200 gBW, 45 mg/200 gBW, and 90 mg/200 gBW. Total cholesterol levels were measured before and after treatment, while kidney tissues were examined histopathologically using HE staining and damage scoring (0–3). Data analysis included Shapiro-Wilk, Kruskal-Wallis, and Spearman’s correlation tests.Results: Most groups showed an increase in cholesterol levels after treatment, except treatment group 2 (45 mg/200 gBW), which demonstrated a decrease from 96.40 mg/dL to 84.40 mg/dL. Kruskal-Wallis test revealed no statistically significant differences among groups (p = 0.306). Histopathological findings indicated that treatment group 2 exhibited lower kidney damage scores compared to the negative control, suggesting a protective effect. Spearman’s correlation analysis showed no significant relationship between day-14 blood glucose levels and total cholesterol (r = –0.130; p = 0.492). Conclusion: Beetroot extract at a dose of 45 mg/200 gBW demonstrated potential in lowering total cholesterol levels and providing nephroprotective effects, although the results were not statistically significant. These findings support the potential role of beetroot as an adjuvant therapy in diabetes mellitus with dyslipidemia and kidney complications.
Uji efek Hipnotik sedatif ekstrak etanol Batang Jaka Tua (Scoparia dulcis Linn) terhadap Mencit Jantan Galur Swiss Gilbert Lister
SCIENTIA JOURNAL Vol. 13 No. 1 (2024): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Abstract

This study aims to evaluate the hypnotic and sedative effects of ethanol extract from the stem of Jaka Tua (Scoparia dulcis Linn) on male Swiss strain mice. The sleep time method with sodium pentobarbital induction was used to assess the extract’s potential to enhance sleep duration. The experiment was conducted at the laboratory of Universitas Adiwangsa Jambi. Mice were divided into five treatment groups: a negative control group (distilled water), a positive control group (diazepam 1 mg/kgBW), and three groups receiving the ethanol extract of Scoparia dulcis stems at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW. Observed parameters included sleep onset time and total sleep duration. Results showed that administration of the extract at 200 mg/kgBW and 400 mg/kgBW significantly increased sleep duration and decreased sleep onset time compared to the negative control. The sedative effect at the highest dose approached that of diazepam. These findings suggest that the stem extract of Scoparia dulcis Linn possesses potential as a natural sedative agent.
Co-Authors Angie, Evelyn Jesika, Jesika