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All Journal Jurnal Impresi Indonesia Jurnal Pendidikan Indonesia (Japendi)
Hapsari, Retno Niken
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Religion Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Social Sciences

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Hubungan Antara Kepatuhan Minum Obat Pada Penderita Kusta dengan Tingkat Kematian di Kabupaten Fakfak Tahun 2022-2024 Sunartho, Cathleen Pricilia; Hapsari, Retno Niken; Hertanto, Maria Patricia
Jurnal Pendidikan Indonesia Vol. 6 No. 9 (2025): Jurnal Pendidikan Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/japendi.v6i9.8614

Abstract

Background: Leprosy is an infectious disease caused by the bacterium Mycobacterium leprae. It primarily affects the skin, peripheral nerves, and respiratory tract, leading to neuropathy and long-term consequences, including deformities and disability. It is transmitted through saliva droplets and prolonged close contact with patients. If patients fail to take their medication regularly during leprosy treatment, the leprosy bacteria can become resistant to MDT, potentially leading to treatment failure or even failure to recover. Medication adherence refers to all patients who take their medication regularly until completion of treatment. Objective: This study aims to determine the relationship between medication adherence in leprosy patients and mortality rates in Fakfak Regency. Methods: An observational analytical study with a cross-sectional design was conducted on a total sample of 82 leprosy patients. Data were obtained from the Fakfak Health Office for 2022-2024. Results: The study subjects were 43 (52.4%) male and 39 (47.6%) female. Twenty-eight (82.4%) non-adherent patients died, while six (17.6%) recovered. The chi-square test showed a p-value of 0.000 (p<0.05), indicating a significant relationship between medication adherence in leprosy patients and the mortality rate in Fakfak Regency. Conclusion: There is a relationship between medication adherence in leprosy patients and the mortality rate in Fakfak Regency.
Stevens Johnson Syndrome Toxic Epidermal Necrolysis Overlap Triggered by Paracetamol and Exacerbated by Cephalosporin and Fluorokuinolon: A Case Report Hapsari, Retno Niken; Haroen, Marina
Jurnal Impresi Indonesia Vol. 4 No. 12 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i12.7341

Abstract

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but life-threatening type IV hypersensitivity reactions, characterized by epidermal necrolysis, bules, skin desquamation, and mucosal involvement. Most cases are triggered by medications, with a fairly high mortality rate, especially in TEN. Management requires discontinuation of trigger medications as early as possible, a multidisciplinary approach, and intensive supportive therapy. It was reported that a 40-year-old Russian man with complaints of peeling skin almost all over the body, pain, burning sensation, accompanied by eye and lip disorders. Complaints arise after the consumption of paracetamol and worsen after the administration of ceftriaxone and levofloxacin. Physical examination showed extensive skin and mucosal involvement with a positive Nikolsky mark, BSA 32%. Laboratory tests showed leukocytosis and increased CRP. The diagnosis of SJS is established with the suspected cause of these drugs. Patients receive supportive therapy including antibiotic discontinuation, rehydration, corticosteroids, antihistamines, mucosal protection, wound care, as well as consultations with ophthalmologists and ENTs. The management of SJS requires discontinuation of trigger drugs as early as possible, intensive supportive therapy, and multidisciplinary coordination to reduce complications and mortality.
Co-Authors Haroen, Marina Hertanto, Maria Patricia Sunartho, Cathleen Pricilia