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All Journal Indonesian Journal of Life Sciences
Utama, Andrea Dhieta
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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The Role of Marula Oil in Alleviating Photoaging: Insights into its Bioactive Components Raisinghani, Prettish Kishore; Lestari, Novita Dwi; Suyanto, Kimberly Alexandra; Utama, Andrea Dhieta
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.237

Abstract

Photoaging, caused by prolonged UV exposure, accelerates skin aging through oxidative stress, collagen degradation, and inflammation. With growing consumer demand for natural and sustainable anti-aging solutions, marula oil has gained attention for its potential in mitigating photoaging. Derived from Sclerocarya birrea, marula oil is rich in fatty acids (oleic and palmitic acids) and antioxidants like vitamin C and E. This review investigates marula oil’s bioactive components and their mechanisms of action in alleviating photoaging, focusing on its moisturizing, antioxidant, and photoprotective properties. Moreover, clinical studies examine its ability to improve skin hydration, enhance barrier function, and inhibit enzymes associated with collagen degradation. Despite its promise as a cosmeceutical, long-term studies are necessary to explore its sustained efficacy, molecular pathways, and potential synergy with other natural ingredients.
In-Silico Study of Diphenhydramine and Orphenadrine Binding Affinities to H1 and NMDA Receptors: Implications for Pharmacological Effects Utama, Andrea Dhieta; Widiyanto, Azura Luna; E, Ervin; Elvina, Lia; Cahya, Rachel Josephine; Feliecia, Silvania; Putri, Stevanie
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i1.222

Abstract

Diphenhydramine and orphenadrine are oral drugs designed to possess different functional groups that affect H1 and NMDA receptors, although for different purposes. This study compares their binding affinities with the two receptors to investigate whether it influences the differing pharmacological effects exerted. This could help better understand the mechanisms, benefits, and risks of the drugs. The physicochemical properties were analyzed using Swiss-ADME, while the binding affinities were tested by molecular docking with PyRx. Lastly, visualization and analysis were done using the BIOVIA Drug Discovery Studio. The result suggests that both drugs have the same affinity for H1 receptors, however, orphenadrine has a slightly higher affinity to NMDA than diphenhydramine. This finding suggests that the binding ability and affinity of orphenadrine to NMDA is the factor of its pharmacological effect difference compared to diphenhydramine. Moreover, the difference in the functional group possessed by the two drugs will make a difference in their absorption and distribution.
Co-Authors Cahya, Rachel Josephine E, Ervin Elvina, Lia Feliecia, Silvania Lestari, Novita Dwi Putri, Stevanie Raisinghani, Prettish Kishore Suyanto, Kimberly Alexandra Widiyanto, Azura Luna