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Azhar Syed Sulaiman, Syed
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Problem Kompatibilitas dan Stabilitas Pencampuran Sediaan Intravena Pada Pasien Anak di RSUP Dr. Sardjito Rahmawati, Reza; Rahmawati, Fita; Azhar Syed Sulaiman, Syed
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Inappropriate preparation and administration intravenous drug may caused harm and therapeutic failure for the patient. In pediatric patient, intravenous drug administration is very critical because of poor venous access especially when simultaneously drug administration required which is can lead into incompatibilities occurence. Errors in intravenous drug administration can affect the drug stability also. Therefore, this research aims to investigate the prevalence of incompatibility and stability in pediatric hospitalized patient. This research was done with prospective study at RSUP Dr. Sardjito in Pediatric Intensive Care Unit (PICU) and pediatric ward from November-December 2017. Data collection was done with pediatric hospitalized patient that used at least 1 intravenous drug. Compatibility and stability were analyzed using standard reference Handbook of Injectable Drugs and other references. A total pediatric hospitalized patients are 75 patients, 34 patients are from PICU and 41 patients are from pediatric ward. Intravenous drugs used are 49.1% with the mean of intravenous drugs are 3.3 drugs/patient. Compatible drug combinations are 73.3% and unknown are 26.3%. There are no incompatible drug combination found in this research. Stability problems were found in 3 drug combination that administered by continuous infusion.
Problem Kompatibilitas Pemberian Obat secara Intravena pada Pasien di Intensive Care Unit Haqoiroh; Rahmawati, Fita; Azhar Syed Sulaiman, Syed
Jurnal Farmasi (Journal of Pharmacy) Vol. 7 No. 1 (2018): Jurnal Farmasi (Journal of Pharmacy), October 2018
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Intravenous administration of drugs is commonly used in hospitals patients who need rapid pharmacological effects or when patients can not take oral administration. Preparation for intravenous administration of drugs need special condition because there are some risks include incompatibilities. The aim of this study is to investigate the prevalence of intravenous drug incompatibilities such as drug incompatibilities in Intensive Care Units patients at RSUP Dr. Sardjito and UGM Hospital, and to find the risk factor that affect of drug incompatibilities such as length of hospital stay, number of drugs, and caused of hospitalization.This study was a cross-sectional, prospective, and multicenter in RSUP. Dr. Sardjito and Academic UGM Hospital, Yogyakarta. The location of this study were in ICU, ICCU, and HCU. The prevalence of potential drug incompatibility were analyzed with description statistics and the association between potential incompatibilities and risk factors will be investigated using student t test and ANOVA with 95% confidence interval. 65 patients were collected from this research. The prevalence of potential drug incompatibilities (PI) were found in 28 prescriptions with ratio PI 2.4 incompatibility/patient. The highest incompatibility type was precipitation of 42 (83,35%) and the most precipitating drug pairs are fentanyl and phenytoin; midazolam and phenytoin. The number of drugs were significantly related with PI.
Co-Authors Fita Rahmawati Haqoiroh Rahmawati, Reza