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All Journal Jurnal Masyarakat Madani Indonesia Bhakta Dental Journal
Efrata, Eka Resti
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Pengaruh Penambahan Ellagic Acid pada Karbonat Apatit terhadap Jumlah Sel Makrofag pada Proses Penyembuhan Defek Tulang Nurmala Dewi, Aulia; Septommy, Catur; Setiawati, Herautami Caezar Yulia; Primasari, Dyah Noviana; Efrata, Eka Resti
Bhakta Dental Journal Vol 2 No 1 (2024): Juni
Publisher : Fakultas Kedokteran Gigi IIK Bhakti Wiyata, Kediri.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/bhaktadent.v2i1.42

Abstract

Background: Bone defects are a problem that can occur in the field of dentistry such as sockets after tooth extraction and periodontitis. The therapy that must be used in cases of bone defects is to use a bone graft. Apatite carbonate is a calcium phosphate biomaterial that has biocompatibility, bioactivity and osteoconductive properties. Ellagic acid is a phenolic compound that can provide anti-inflammatory effects, when applied to scars it can reduce macrophage cells by inhibiting the expression of pro-inflammatory cytokines IL-1 and TNF-α and stimulating anti-inflammatory cytokines and growth factors TGF-B and VEGF. Objective: To determine the effect of adding ellagic acid to carbonic apatite on the number of macrophage cells in the healing process of bone defects. Methods: This type of laboratory experimental research with the Post Test Only Control group design. The research sample used 21 male Wistar rats which were divided into 3 treatment groups, namely group 1 was treated with PEG, group 2 was treated with CHA and group 3 was given CHA + EA. Observation of the number of macrophages was carried out on the 5th day. Data analysis used Oneway Anova and continued with the LSD test. Results: the one-way Annova test yielded a sig 0.00 (p <0.05) indicating that overall there was a significant difference. The results of the LSD test showed significant differences between the study groups. Conclusion: The addition of ellagic acid to carbonic apatite affects the number of macrophage cells in the healing process of bone defects in Wistar rats (Rattus novergicus). Keywords: Juice macrophage cells, ellagic acid and carbonic apatite
Peningkatan Pengetahuan Kesehatan Gigi dan Mulut melalui Edukasi pada Siswa SMA di Kota Malang Prakosa, Basma Rosandi; Setiawan, Fery; Primasari, Dyah Noviana; Efrata, Eka Resti; Septommy, Catur
Jurnal Masyarakat Madani Indonesia Vol. 5 No. 2 (2026): Mei (In Progress)
Publisher : Alesha Media Digital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59025/np9wbb24

Abstract

Permasalahan kesehatan gigi dan mulut pada remaja masih menjadi tantangan di Indonesia, terutama terkait rendahnya kesadaran dan kebiasaan menjaga kebersihan oral. Siswa sekolah menengah atas di Kota Malang menunjukkan kebutuhan peningkatan literasi kesehatan yang tidak hanya pada tingkat mengetahui, tetapi juga memahami dan mampu menerapkan perilaku menjaga kesehatan gigi dan mulut secara mandiri. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan serta kesadaran siswa melalui edukasi interaktif menggunakan media presentasi visual dan booklet secara tatap muka. Metode pelaksanaan dilakukan melalui tahapan pre-test, pemberian materi edukasi, diskusi partisipatif, dan post-test untuk mengevaluasi perubahan capaian pengetahuan peserta. Sebanyak 400 siswa dari SMAN 2 dan SMAN 4 Kota Malang terlibat dalam kegiatan ini. Hasil evaluasi menunjukkan adanya peningkatan skor pengetahuan siswa, dimana nilai rata-rata pre-test sebesar 56,58 ± 12,526 meningkat menjadi 84,28 ± 12,585 pada post-test. Analisis statistik menggunakan Wilcoxon signed-rank test menunjukkan perbedaan yang signifikan (p < 0,05). Temuan ini menunjukkan bahwa pendekatan edukasi interaktif berbasis media visual efektif dalam meningkatkan pengetahuan kesehatan gigi dan mulut pada remaja serta berpotensi dikembangkan sebagai model promosi kesehatan berbasis sekolah secara berkelanjutan.
Co-Authors Fery Setiawan Nurmala Dewi, Aulia Prakosa, Basma Rosandi Primasari, Dyah Noviana Setiawati, Herautami Caezar Yulia