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All Journal Jurnal EduHealth Quantum Wellness : Jurnal Ilmu Kesehatan Pharmacia
Wury Damayantie
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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STUDI LITERATUR AKTIVITAS ANTIBAKTERI DARI EKSTRAK DAUN JARAK PAGAR (Jatropha curcas Linn.) TERHADAP BERBAGAI SAMPEL BAKTERI: STUDI LITERATUR AKTIVITAS ANTIBAKTERI DARI EKSTRAK DAUN JARAK PAGAR (Jatropha curcas Linn.) TERHADAP BERBAGAI SAMPEL BAKTERI Irmayanti, Irmayanti; Linda Fauziah Ariyani; Wury Damayantie
PHARMACIA Vol. 1 No. 1 (2023): Pharmacy
Publisher : Program Studi Farmasi Universitas Mulia

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Abstract

Pandemi covid-19 telah memicu peningkatan penggunaan antibiotik, dilaporkan 68,9% pasien covid-19 melaporkan penggunaan antibiotik sebelum masuk rumah sakit yang memicu peningkatan angka resistensi antibiotik. Daun jarak pagar (Jatropha curcas Linn.) merupakan salah satu tanaman obat tradisional yang terbukti memiliki kemampuan antibakteri yang sangat baik. Tanaman ini mengandung berbagai zat yang berpotensi untuk digunakan sebagai obat, menurut berbagai penelitian. Masyarakat masih sering menggunakan berbagai obat tradisional sebagai bentuk pengobatan karena secara historis telah digunakan untuk menyembuhkan penyakit dengan efek samping yang lebih ringan dibandingkan pengobatan modern. Tujuan penelitian adalah untuk mengetahui aktivitas antibakteri ekstrak daun tanaman ini dalam berbagai jenis pelarut. Alkaloid, saponin, tanin, fenol, dan flavonoid merupakan zat aktif yang terdapat pada ekstrak daun dari tanaman ini yang memiliki aktivitas sebagai antibakteri dimana masing-masing senyawa memiliki mekanisme kerja yang berbeda. Metode penelitian berupa studi literatur dengan mengumpulkan sumber-sumber dari jurnal dalam dan luar negeri yang mungkin terdapat secara online dengan menggunakan mesin pencari Google Scholar. Populasi dalam penelitian ini dengan membaca artikel tentang sifat antibakteri ekstrak daun jarak pagar (Jatropha curcas Linn.) Sampel penelitian masing-masing berasal dari sepuluh jurnal nasional dan internasional. Aktivitas antibakteri ekstrak daun tanaman dipelajari dan hasilnya mengungkapkan klasifikasi zona hambat sedang hingga sangat tinggi. Untuk Escherecia coli, Staphylococcus aureus, Staphylococcus epidermis, Pseudomonas aeruginosa, Klebsiella pneumonia, dan Agrobacterium tumifaciens kategori zona hambat sangat kuat. Kategori zona hambat kuat untuk spesies bakteri Aspergillus niger. Bakteri Porphyromonas gingivalis berada pada kelompok zona hambat sedang.
Antibacterial activity and diabetic wound therapy of topical preparations of polyherbal combination extracts in vitro Wury Damayantie
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

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Glucose metabolic disorders in cases of diabetes mellitus (DM) will affect other body metabolism, such as carbohydrate, protein, fat and water metabolism and cause cellular damage to several body tissues.. This research aims to determine the antibacterial activity test in vitro using aerobic bacteria ( S. aureus and P. aeruginosa) based on the MIC value shown in the polyherbal formulation. Then a topical test was carried out on white mice which had previously been induced by STZ-NA with complications of diabetic ulcers characterized by wounds on the mice's backs. The samples used in this research were noni fruit simplicia, insulin leaves, turmeric, aloe vera and honey. Polyherbal plants that are still fresh and complete are determined at BBPPTOOT Tawangmangu, Kab. Karanganyar, Central Java. This research was carried out in-vitro and was a laboratory experiment. The polyherbal ethanol extract obtained was then tested for antibacterial activity against S. aureus and P. aeruginosa at several concentrations (20% and 50%). The test results showed that the concentration that had the most active MIC value was a concentration of 20% of the diameter of the best inhibitory zone, namely honey extract, noni fruit, insulin leaves, turmeric rhizomes, while at a concentration of 50% the diameter of the best inhibitory zone, namely aloe vera. From these results a new formulation series was created, expressed as F1. F1 was then replicated 3 times to get the best antibacterial activity results. From the replication results, the polyherbal formulation had inhibitory power due to the presence of a clear zone around the well. Diameter antibacterial zone of inhibition against Staphylococcus aureus has an inhibition zone diameter of 14.4 mm and Pseudomonas auroginosa has an inhibition zone diameter of 11.67 mm. From this research it was found that the polyherbal formulation hadactive antibacterial activity in inhibiting Staphylococcus aureus and Pseudomonas auroginosa. These results are continued to determine the healing activity of diabetic ulcers. The activity test used Wistar male white rats which were grouped into 10 groups with each group consisting of 5 rats. Rats were induced with STZ at 45 mg/kgBW and NA 110 mg/kgBW, until the rat's blood sugar level was > 250 mg/dL. Measurement of rat blood sugar levels using the GOD-PAP method. The mice were left for 3 weeks until nephropathy occurred, after which the mice's backs were injured using a biopsy punch with a diameter of ± 4 mm.
Karakteristik dan Identifikasi Senyawa Ekstrak Etanol Daun Pacing Tawar (Costus speciosus) Putri Jihannisa; Wury Damayantie; Murtiyana Sari
Quantum Wellness : Jurnal Ilmu Kesehatan Vol. 2 No. 4 (2025): Desember : Quantum Wellness : Jurnal Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/quwell.v2i4.2503

Abstract

The wild ginger leaves (Costus speciosus) is used by the community as a traditional medicine, with its rhizome being utilized as an antipyretic, diuretic and anti-inflammatory agent. This plant contains secondary metabolite compounds such as alkaloids, flavonoids, polyphenols, quinones, tannins and saponins. This research aims to identify saponin compounds and characterize the moisture content and ash content in the ethanol extract of the white costus (Costus speciosus) leaves. The white costus leaves sample was extracted using the maceration method with 96% ethanol as the solvent. The extraction yielded a rendemen value of 13.3%. Non-specific characterization tests included moisture content and ash content. The results for the moisture content of the white costus leaf simplicia were 3.3%, which meets the quality requirement of not more than 10% according to Regulation of the Food and Drug Supervisory Agency Number 32 of 2019. The ash content test result for the simplicia was 0.97%, which also meets the standard requirement of the Indonesian Herbal Pharmacopoeia, which is less than 10.7%. Phytochemical screening was conducted to identify the types of compounds contained in the extract. Based on the phytochemical screening results, the 96% ethanol extract of white costus leaves positively contains alkaloids, tannins, saponins, and steroids.
Analisis Senyawa Saponin pada Ekstrak Etanol Daun Pacing Tawar (Costus speciosus) Fitriani Fitriani; Wury Damayantie; Murtiyana Sari
Quantum Wellness : Jurnal Ilmu Kesehatan Vol. 2 No. 4 (2025): Desember : Quantum Wellness : Jurnal Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/quwell.v2i4.2504

Abstract

Pacing tawar is one of many plants used in alternative medicine. Pacing tawar is often used as an ingredient in herbal remedies for various ailments. Pacing leaves are effective as a remedy for itching, insect bites, and hair growth. This study aims to identify the presence and class of secondary metabolites in the ethanol extract of pacing tawar leaves to find bioactive compounds that have the potential to have pharmacological and therapeutic activities. Extraction was carried out by the maceration method using 96% ethanol solvent until a thick extract was obtained. Next, phytochemical screening was carried out to identify the content of alkaloids, flavonoids, saponins, tannins, and steroids. The test results showed that the extract of pacing tawar leaves was positive for alkaloids, saponins, tannins, and steroids, and negative for flavonoids. The alkaloid test showed a dark pink color change, the saponin test produced a 2 cm high foam for 30 seconds, the tannin test produced a dark green color, and the steroid test showed a faint red ring. Based on these results, it can be concluded that freshwater pacing leaves contain various bioactive compounds that have the potential to be developed as natural medicinal ingredients.
Co-Authors Fitriani Fitriani Irmayanti Irmayanti, Irmayanti Linda Fauziah Ariyani Murtiyana Sari Putri Jihannisa