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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Biologi Tropis Cermin Dunia Kedokteran
Tri Wirattami, Ayunita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Danyoung Classification Correlation with The Severity of Allergic Rhinitis and Symptoms Duration Tri Wirattami, Ayunita; Agustina, Tanti
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.9974

Abstract

The Danyoung classification characterizes progressive endoscopic changes in the nasal mucosa of allergic rhinitis (AR) patients, but its clinical correlation with disease severity and chronicity remains unestablished. This cross-sectional study aimed to determine the association between Danyoung stages (1: hypertrophic, 2: dimple, 3: wrinkled) and AR symptomatology. Fifty AR patients from a tertiary allergy-immunology clinic were enrolled over a six-month period. Data on symptom duration, profile, and ARIA-based severity (intermittent/persistent, mild/moderate-severe) were collected. Nasoendoscopic examination was performed for Danyoung staging. Statistical analysis using chi-square tests demonstrated no significant association between Danyoung stage and symptom duration (p=0.85) or clinical disease severity (p=0.96). The findings indicate that the Danyoung classification, as an objective morphological descriptor, is not a statistically significant predictor of symptom-based AR severity or chronicity in this patient cohort. This suggests that the progression of endoscopic nasal mucosal changes may follow a pathway independent of the clinical parameters defined by ARIA guidelines, limiting its utility as a standalone clinical prognostic tool.
The Relationship Between Total IgE, Symptom Duration, VAS Scores, and Danyoung Classification in Allergic Rhinitis Tri Wirattami, Ayunita; Agustina, Tanti
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.957-960

Abstract

Allergic Rhinitis (AR) is an inflammatory condition of the nasal mucosa triggered by allergies, with total IgE often used as a biomarker to assess disease severity. Objective: To analyze the relationship between total IgE levels, symptom duration, Visual Analog Scale (VAS) scores, and Danyoung Classification in AR patients. Methods: A cross-sectional observational analytical study was conducted on 73 patients at the Allergy-Immunology Clinic of Dr. Saiful Anwar General Hospital. Total IgE levels were measured using the ELISA method, while VAS and nasal mucosa classification were assessed through anamnesis and nasoendoscopy. Results: The study showed68.5% of patients had IgE levels above 100 IU/ml, with an average of 982.97 IU/ml. Although higher IgE levels were often found in AR patients, there was no statistically significant correlation between IgE levels and Danyoung classification (significance value 0.924). The correlation test showed a coefficient of -0.11, indicating a negative correlation, but it was not statistically significant. Conclusion: The nasal mucosa condition in patients with high IgE levels does not always reflect severe inflammation. In addition to IgE levels, external factors such as exposure to pollutants and cigarette smoke also play a role in the condition of the nasal mucosa. Therefore, while high IgE levels often indicate allergic reactions, this study found no significant relationship between IgE levels and AR severity.
Hipertrofi Adenoid dan Tonsil sebagai Faktor Risiko Obstructive Sleep Apnea pada Anak di RSUD Dr. Saiful Anwar Malang Periode 1 Januari 2015 – 31 Desember 2017 Tri Wirattami, Ayunita; Dwijo Murdiyo, H. Muhammad
Cermin Dunia Kedokteran Vol 49 No 10 (2022): Oftalmologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i10.302

Abstract

Pendahuluan: Obstructive sleep apnea (OSA) adalah bagian dari sleep disorder breathing syndrome. Prevalensi OSA pada anak-anak sekitar 3% dengan frekuensi tertinggi pada usia 3-6 tahun. Penyebab utama OSA pada anak-anak adalah hipertrofi tonsil dan adenoid. Metode: Penelitian deskriptif untuk mengetahui kejadian hipertrofi adenoid dan tonsil pada anak dengan OSA di bagian THT-KL di RSUD Dr. Saiful Anwar Malang periode 1 Januari 2015 – 31 Desember 2017. Hasil: Selama periode tersebut tercatat 9 pasien hipertrofi adenoid dan tonsil anak, 4 orang laki-laki dan 5 orang perempuan; terbanyak pada rentang usia 5-10 tahun. Dari 9 subjek, 2 orang dengan hasil PSG normal, 7 orang menderita OSA sedang, 2 orang dengan hasil PSG normal, 7 orang dengan OSA, di mana terbanyak adalah OSA sedang. Ukuran hipertrofi adenoid terbanyak (44,4%), yaitu grade 1, 3, dan 4 dengan OSA, dengan paling banyak OSA sedang, sedangkan ukuran tonsil terbanyak (44,4%) adalah T3-T3 dengan derajat OSA sedang dan berat. Sebanyak 6 orang dengan BMI normal dan menderita OSA sedang, 1 orang dengan obesitas menderita OSA berat. Simpulan: Hipertrofi adenoid dan tonsil tidak berbanding lurus dengan derajat OSA, namun makin meningkatnya BMI dapat meningkatkan derajat OSA.   Introduction: Obstructive sleep apnea (OSA) is part of the complex respiratory syndrome sleep disorder. The prevalence of OSA in children is around 3% with the highest frequency at 3-6 years old. The main cause of OSA in children are tonsillar and adenoid hypertrophy. Method: A descriptive study to assess adenoid and tonsillar hypertrophy incidence among children with OSA in the Otorhinolaryngology Department, Dr. Saiful Anwar General Hospital, Malang, during 1 January 2015 – 31 December 2017. Results: There were 9 children registered with tonsillar and adenoid hypertrophy, 4 males and 5 females, mostly within age range of 5-10 years; 2 with normal PSG results, 7 with OSA, mostly moderate OSA. The size of adenoid hypertrophy were grades 1, 3, and 4 (44.4%) with moderate OSA, while 44.4% tonsil size were T3-T3 with moderate and severe OSA. A total of 6 children with normal BMI and moderate OSA, 1 person with obesity suffered from severe OSA. Conclusion: Adenoid and tonsillar hypertrophy is not directly proportional to the degree of OSA, but increasing BMI can worsen OSA.
Co-Authors Agustina, Tanti Dwijo Murdiyo, H. Muhammad