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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Saleh, Ahmed Hamad
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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ELEVATE SOME TYPES OF ADIPOKINES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS) Alrawi, Nawfal N. R.; Saleh, Ahmed Hamad
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 7 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i7.715

Abstract

The current work aimed to estimate some types of Adipokines (Leptin, adiponectin and the resistin) in PCOS women. The participants belong to both PCOS women and healthy women were selected and examined in Azadi teaching hospital at September 2021 to February 2022. 80 patients with 30 controls were used in this study. The current outcomes show the concentration of Leptin in PCOS patients, where concentration of Leptin demonstrated significant (P <0.05) elevate in PCOS women compared with healthy women. Adiponectin concentration in PCOS women indicated significant (P <0.05) reduce compared with healthy women. Resistin concentration in PCOS women indicated significant (P <0.05) raise compared with healthy women. So, based on this findings, PCOS lead to significant (P <0.05) differences in concentration of some types of Adipokines.
EVALUATION OF THE EFFECT OF FLAVONOIDS ISOLATED FROM SILYBUM MARIANUM ON LYMPHOCYTES OF ADULT FEMALE RATS AND THEIR FETUSES (MTT ASSAY) Saleh, Ahmed Hamad
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 12 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i12.1507

Abstract

Objective: This study aimed to evaluate the effects of flavonoids isolated from Silybum marianum (milk thistle) on the lymphocytes of adult female rats and their fetuses, focusing on cytotoxicity and compound characterization. Method: Fresh leaves collected from Sulaymaniyah, Iraq, in January 2025 were subjected to flavonoid extraction and analyzed using High Performance Liquid Chromatography (HPLC) and Fourier Transform Infrared Spectroscopy (FT-IR) to identify phenolic compounds. Lymphocytes were isolated from rat blood samples via density gradient sedimentation, and MTT assays were performed to assess cell viability at different extract concentrations (25, 50, and 100 μg/ml). Results: HPLC analysis identified several flavonoids, with 4-hydroxyl benzoic acid (282.5 ppm) and catechol (233.1 ppm) being the most abundant. Cytotoxicity tests showed high lymphocyte viability for both adult females (92.34–81.35%) and fetuses (91.92–81.7%), with IC₅₀ values of 324.9 μg/ml and 347.3 μg/ml, respectively. Novelty: The study demonstrates that S. marianum leaf extracts are rich in bioactive flavonoids with low cytotoxic effects on lymphocytes, suggesting potential for safe therapeutic use in antioxidant or protective applications.
Co-Authors Alrawi, Nawfal N. R.