Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Oblokulova O.A
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
CLINICAL AND DIAGNOSTIC CRITERIALS OF LIVER FIBROSIS FORMATION IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C WITH EXTRAHEPATIVE MANIFESTATIONS Narziyev I.I; Oblokulova O.A; Tohirov F.F
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.1008

Abstract

Background: Chronic viral hepatitis C (CVHC) is often associated with various extrahepatic manifestations, which may complicate the disease's progression. Specific Background: Cryoglobulinemia, characterized by the presence of cryoglobulins in the blood, has been implicated in the exacerbation of liver conditions, yet its role in CVHC remains inadequately explored. Knowledge Gap: Despite existing knowledge of the relationship between cryoglobulinemia and liver disease, the specific impact of cryoglobulinemia on the severity of liver fibrosis and associated extrahepatic manifestations in CVHC patients requires further elucidation. Aims: This study aims to investigate the prevalence of extrahepatic manifestations and the extent of liver fibrosis in patients with CVHC who also present with cryoglobulinemia, thereby determining the clinical implications of cryoglobulin presence. Results: Our findings indicate that patients with cryoglobulinemia demonstrate a significantly higher prevalence of extrahepatic manifestations and advanced stages of liver fibrosis compared to those without cryoglobulinemia. Novelty: This research contributes novel insights into the aggravating role of cryoglobulins in the clinical course of CVHC, highlighting their potential as biomarkers for disease severity. Implications: These results underscore the need for enhanced clinical monitoring and tailored therapeutic approaches for CVHC patients with cryoglobulinemia, as their condition may predict a more severe disease trajectory and necessitate more aggressive management strategies.
LABORATORY CHARACTERISTICS OF PATIENTS WITH LIVER CIRRHOSIS OF VIRUS ETIOLOGY COMPLICATED WITH SPONTANEOUS BACTERIAL PERITONITIS Oblokulov A.R; Oblokulova O.A; Bahronov O. O
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.1009

Abstract

Background: Systemic inflammation plays a crucial role in the pathophysiology of various diseases, particularly in patients with liver cirrhosis. Specific Background: The Neutrophil-to-Albumin Percentage Ratio (NPAR) has emerged as a novel biomarker for assessing systemic inflammation. Low serum albumin levels combined with elevated neutrophil counts have been associated with an increased risk of infections, including spontaneous bacterial peritonitis (SBP), a serious complication in cirrhotic patients. Knowledge Gap: Despite the recognized risks and mortality associated with SBP, the specific role of NPAR in predicting outcomes in patients with cirrhotic ascites remains underexplored. Aims: This study aims to evaluate the predictive value of NPAR in identifying patients at high risk for developing SBP and to assess its association with in-hospital mortality rates. Results: Our findings indicate that elevated NPAR is significantly correlated with the incidence of SBP and is associated with higher in-hospital mortality, reinforcing the potential of this biomarker in clinical practice. Novelty: This research provides new insights into the utility of NPAR as a predictive tool for SBP in cirrhotic patients, potentially guiding clinicians in early diagnosis and intervention. Implications: By highlighting the importance of NPAR, this study advocates for its incorporation into routine clinical assessments to improve patient outcomes, emphasizing that timely diagnosis and appropriate treatment of SBP can significantly reduce mortality rates.
Co-Authors Bahronov O. O Narziyev I.I Oblokulov A.R Tohirov F.F