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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Ibragimov Shavkat Narzikulovich
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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COMPARISON OF THE ANTITUMOR EFFECT OF KOLHIPRIT-NEO WITH THE EFFECT OF COMMERCIAL DRUGS Makhmudovna Urozov, Enikeeva Zulfiya; Nuriddin Elmuratovich; Agzamova Nigora Alimukhamedovna; Ibragimov Shavkat Narzikulovich; Shakhanova Shakhnoza Shavkatovna
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 11 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i11.1041

Abstract

Objective: In this study, mice with transplanted Sarcoma 180 and Solid Ehrlich tumors (SET) were used to test the antitumor activity of oral K-20 (colchiprit-neo) against different cytostatics. Methods: Antitumor activity was tested in outbred mice with transplanted tumors, treated orally with K-20 and XELODA, and intraperitoneally with doxorubicin, taxol, etoposide, or other cytostatics. Treatment was began on the 4th-5th day post-transplantation, delivered daily for 10 days. Tumor growth inhibition (TGI), animal body and spleen weight, and hematopoietic indices were measured, with statistical significance set at p < 0.05. Results: While other treatments showed significant reductions in hematopoietic parameters, K-20 treatment did not significantly affect body or spleen weight or leukocyte levels. K-20 showed superior antitumor activity, inhibiting tumor growth by 92-94% in Sarcoma 180 and SET models, outperforming doxorubicin (90%) and taxol (84-88%), and demonstrating 27% greater efficacy than XELODA. Novelty: In contrast to conventional cytostatics, K-20's oral administration demonstrated strong anticancer effects along with a good safety record and little influence on hematopoiesis or organ weights.
STUDY OF TOXICOLOGY OF THE ANTITUMOR DRUG COLCHIPRIT-NEO (K-20) Leonidovna, Vypova Natalia; Nishanov Danier Anarbaevich; Madaliev Akhror Alievich; Ibragimov Shavkat Narzikulovich; Enikeeva Zulfiya Makhmudovna; Urozov Nuriddin Elmuratovich
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 11 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i11.1045

Abstract

Objective: Colchiprit-neo was administered orally to rats at dosages of 30.0, 61.0, and 120 mg/kg for 30 days in order to assess its chronic toxicity. Methods: The effects on behavior, body weight, peripheral blood composition, kidney function, liver enzyme levels, and internal organ pathology were evaluated after rats were given Colchiprit-neo at the recommended dosages. To assess the reversibility of any possible harmful effects, a one-month recovery time was incorporated. Results: According to the study, rats' behavior, body weight, and blood composition were unaffected by repeated oral treatment of Colchiprit-neo. During therapy, the liver's alanine aminotransferase (ALT) level rose, but during the recovery phase, all tested values went back to normal. The 30 mg/kg dose did not cause any toxicity in the parenchymal organs, according to pathomorphological analysis. Novelty: The findings indicate that Colchiprit-neo is safe for long-term usage because it does not show substantial chronic toxicity at therapeutic levels. This work offers significant preclinical evidence in favor of its possible therapeutic use without endangering the major organ systems.
Co-Authors Agzamova Nigora Alimukhamedovna Enikeeva Zulfiya Makhmudovna Leonidovna, Vypova Natalia Madaliev Akhror Alievich Makhmudovna Urozov, Enikeeva Zulfiya Nishanov Danier Anarbaevich Nuriddin Elmuratovich Shakhanova Shakhnoza Shavkatovna Urozov Nuriddin Elmuratovich