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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
AL-Ukaily, Hussein Ali Mohammed
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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INVESTIGATING THE ROLE OF B-CELL ACTIVATING FACTOR (BAFF), GALECTIN-9, AND CD73 IN THE PATHOGENESIS OF VITILIGO: A CORRELATIVE STUDY WITH BIOCHEMICAL FACTORS AL-Ukaily, Hussein Ali Mohammed
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1073

Abstract

Objective: To investigate the involvement of immune-regulatory molecules—B-cell Activating Factor (BAFF), Galectin-9, and CD73—in the pathogenesis of vitiligo. Methods: A case-control study involving 50 patients with active vitiligo and 50 healthy controls. Peripheral blood and skin biopsy samples were collected to measure the concentrations of BAFF, Galectin-9, and CD73. Statistical analysis was conducted to evaluate differences and correlations between these markers. Results: The results showed that the levels of B-cell Activating Factor (BAFF) were significantly higher in vitiligo patients (150.64 ng/mL) compared to healthy controls (85.16 ng/mL). Similarly, Galectin-9 concentrations were elevated in patients (203.02 ng/mL) relative to controls (149.68 ng/mL). In contrast, CD73 levels were lower in vitiligo patients (49.66 ng/mL) compared to healthy controls (79.37 ng/mL), although this difference was not statistically significant. Correlation analysis revealed a positive association between BAFF and Galectin-9, while CD73 exhibited a negative correlation with both BAFF and Galectin-9. Novelty: The study identifies BAFF and Galectin-9 as potential biomarkers for vitiligo severity and suggests CD73 as a modulator of immune responses. This adds new insights into the immunopathology of vitiligo and highlights potential therapeutic targets
THE IMPACT OF SLEEP DISORDERS ON CELLULAR IMMUNE REGULATION AMONG UNIVERSITY STUDENTS AL-Ukaily, Hussein Ali Mohammed; Al-Saadi, Zainab Nashaat Shukur
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 7 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i7.1346

Abstract

Objective: Sleep is a fundamental biological process that contributes to regulating physiological balance within the body, particularly in maintaining the efficiency of the immune system. Recent literature indicates that sleep disturbances, especially chronic ones, may lead to impaired cellular immune function and increased general inflammatory activity. Based on this hypothesis, this study aimed to evaluate the impact of sleep disturbances on cellular immune regulation in university students by analyzing lymphocyte ratios and concentrations of certain immune cytokines in the blood. Method: The study included (60) male and female students aged (19–24) years, divided into two groups: a group with sleep disturbances (n = 30), identified based on the Pittsburgh Sleep Quality Index questionnaire (PSQI ≥ 6), and a control group (n = 30) with normal sleep patterns. Immune cell ratios (CD3+, CD4+, CD8+, and CD56+) were measured using flow cytometry, while the concentrations of the cytokines IL-6, TNF-α, and IFN-γ were determined using enzyme-linked immunosorbent assay (ELISA). Result: The results showed a significant decrease in the percentages of CD3+, CD4+, and CD56+ cells in the sleep disorder group compared to the control group (p < 0.01), while no significant differences were recorded in the percentages of CD8+ cells. Regarding cytokines, a significant increase in the concentrations of IL-6 and TNF-α was found in those with sleep disorders (p < 0.01), while there was no significant difference in the level of IFN-γ. The study also revealed a moderate positive correlation between PSQI scores and IL-6 concentrations (r = 0.58, p < 0.01), indicating that poor sleep quality is associated with increased immune inflammation. Novelty: These findings highlight the negative biological impact of sleep disturbances on cellular immune function in young university students, and suggest a potential causal relationship between poor sleep quality and the activation of inflammatory pathways.
Co-Authors Al-Saadi, Zainab Nashaat Shukur