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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Sahib Abdulhasan, Rawaa
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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THE IMPACT OF INFLAMMATION ON DIABETES: PHYSIOLOGICAL PATHWAYS AND CLINICAL OUTCOMES Sahib Abdulhasan, Rawaa
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1076

Abstract

Objective: To investigate the role of inflammation in diabetes, its impact on physiological pathways, clinical outcomes, and potential therapeutic strategies. Methods: A comprehensive review of existing literature was conducted to elucidate the mechanisms linking inflammation with diabetes and evaluate the clinical implications and emerging therapeutic approaches. Results: Inflammation significantly contributes to the onset and progression of diabetes. In type 2 diabetes, chronic low-grade inflammation, driven by pro-inflammatory cytokines like TNF-α and IL-6, disrupts insulin signaling, leading to insulin resistance. Oxidative stress induced by inflammation further deteriorates beta-cell function, impairing insulin production. In type 1 diabetes, autoimmune-induced inflammation destroys pancreatic beta cells, triggering hyperglycemia. Clinically, elevated markers such as CRP are correlated with complications like cardiovascular diseases, neuropathy, and nephropathy. Anti-inflammatory therapies show promise in improving glycemic control and reducing complications. Novelty: This study highlights the intricate link between inflammation and diabetes, emphasizing novel therapeutic strategies targeting inflammation to address glycemic control and mitigate disease-related complications. Understanding these mechanisms is essential for combating the global diabetes epidemic.
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