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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Sokhiba Ziyadulloyevna, Khakimova
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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NERVOUS SYSTEM DAMAGE IN HIV INFECTION AND AIDS Jasur Mukhammadi Oʻgʻli, Egamberdiev; Umid Arzikulovich, Qodirov; Sokhiba Ziyadulloyevna, Khakimova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1176

Abstract

Objective: This study aims to explore the neurological complications of HIV infection, specifically the impact of HIV on the nervous system, including the role of the glycoprotein gp120 in neuronal damage. Methods: A review of HIV-related neurological impairments, focusing on the mechanisms of viral infection and the consequences on glial and neuronal cells, was conducted. The study examines the direct and indirect damage caused by the virus and associated factors such as opportunistic infections, tumors, and the effects of antiretroviral drugs. Results: : The study finds that HIV infection affects approximately one in every hundred cells in brain tissue, significantly impacting glial cells, neurons, and other cells possessing the CD4 receptor. HIV damages these cells through direct infection and by the destructive effects of the gp120 glycoprotein, which leads to membrane lysis and neurotoxic consequences such as an increased Ca2+ ion load in astrocytes. Novelty: This research highlights the critical role of gp120 in the pathogenesis of HIV-induced neuronal damage, specifically its interference with neuroleukin and the glutamate retention mechanisms in astrocytes, which are key to understanding HIV-related neurological disorders.
PATHOGENESIS OF DIABETIC POLYNEUROPATHY AND MODERN SOLUTIONS FOR CLINICAL DIAGNOSIS Dilmurod Do‘stmamat Oʻgʻli, Nematullayev; Umid Arzikulovich, Qodirov; Sokhiba Ziyadulloyevna, Khakimova
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 2 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i2.1177

Abstract

Objective: Diabetic polyneuropathy encompasses a spectrum of symptoms signaling damage to nerve fibers and impaired functionality, primarily driven by prolonged hyperglycemia. Methods: This condition arises due to metabolic dysfunction in the body, often linked to decompensated diabetes mellitus, leading to progressive nerve cell deterioration. Results: : Patients exhibit reduced limb sensitivity, which, in severe cases, may escalate to complete sensory loss. Novelty: The study underscores the intricate relationship between sustained hyperglycemia and the gradual degeneration of nerve cells, highlighting the critical need for targeted interventions to prevent or mitigate nerve damage in diabetic patients.
Co-Authors Dilmurod Do‘stmamat Oʻgʻli, Nematullayev Jasur Mukhammadi Oʻgʻli, Egamberdiev Umid Arzikulovich, Qodirov