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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Mavludaxon Mirxamzayevna, Mamurova
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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DIRECT EFFECT OF COMORBID MENTAL DISORDERS ON THE CLINICAL COURSE OF ALCOHOLISM Akmal Axmadjonovich, Gaybiyev; Mavludaxon Mirxamzayevna, Mamurova; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1201

Abstract

Objective: This study aims to investigate the direct effect of comorbid mental disorders on the clinical course of alcoholism, emphasizing the complexities involved in diagnosis, treatment, and rehabilitation. Method: A comprehensive analysis was conducted through a cross-sectional study involving patients diagnosed with alcohol use disorder (AUD) and co-occurring mental health conditions. Data were collected using standardized psychiatric assessments and clinical evaluations from both narcology and psychiatry specialists. Results: The findings reveal that the presence of comorbid mental disorders significantly exacerbates the severity and chronicity of alcoholism, leading to poorer treatment outcomes, increased relapse rates, and heightened resistance to standard therapeutic interventions. Patients with dual diagnoses exhibited more complex clinical profiles, necessitating integrated and multidisciplinary treatment approaches. Novelty: This study highlights the critical need for dual-specialist involvement in the management of AUD with comorbid mental disorders, offering new insights into integrated treatment frameworks that can enhance clinical outcomes and reduce the burden of relapse.
RISK FACTORS FOR THE DEVELOPMENT OF RENAL PATHOLOGY, CARDIOVASCULAR AND CEREBROVASCULAR SYSTEMS Malikaxon Mirxamzayevna, Mamurova; Mavludaxon Mirxamzayevna, Mamurova; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 4 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i4.1202

Abstract

Objective: This study aims to identify and analyze common risk factors contributing to the development of renal pathology, cardiovascular diseases, and cerebrovascular disorders, highlighting the interconnected pathophysiological mechanisms among these systems. Method: A comprehensive literature review and comparative analysis were conducted to examine the overlapping pathogenetic pathways and shared risk factors across renal, cardiovascular, and cerebrovascular conditions. The study synthesized data from peer-reviewed articles, clinical studies, and epidemiological reports to identify key mechanisms influencing disease progression. Results: The analysis revealed that risk factors such as hypertension, diabetes mellitus, dyslipidemia, smoking, and chronic inflammation are common to all three systems, contributing to endothelial dysfunction, atherosclerosis, and impaired vascular regulation. These shared mechanisms underscore the parallel progression of pathology within the brain, heart, and kidneys, increasing the susceptibility to comorbid conditions. Novelty: This study provides new insights into the integrated pathophysiological processes linking renal, cardiovascular, and cerebrovascular diseases, emphasizing the need for holistic prevention strategies and multidisciplinary management approaches to address these interrelated health risks effectively.
MODERN METHODS OF DIAGNOSING AND TREATING NEUROLOGICAL CHANGES OBSERVED IN ALCOHOLISM Shuxrat Toshtemirovich, Niyozov; Mavludaxon Mirxamzayevna, Mamurova; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1203

Abstract

Objective: This study aims to explore modern methods of diagnosing and treating neurological changes associated with alcoholism, with a focus on understanding the pathological mechanisms underlying alcohol dependence and its impact on the nervous system. Method: A systematic review of recent clinical studies, diagnostic criteria from DSM-5, and neuroimaging techniques was conducted to evaluate current diagnostic tools and therapeutic approaches. The analysis included neuropsychological assessments, biomarker identification, and pharmacological interventions targeting alcohol-induced neurological impairments. Results: Findings indicate that advanced neuroimaging techniques, such as MRI and PET scans, along with neurocognitive testing, are effective in detecting alcohol-related neurological damage. Pharmacological treatments, including the use of naltrexone, acamprosate, and disulfiram, combined with cognitive-behavioral therapy, show significant efficacy in managing alcohol cravings and mitigating neurological deterioration. Novelty: This study highlights the integration of neuroimaging biomarkers with personalized pharmacological and behavioral interventions as a novel approach for improving diagnostic accuracy and treatment outcomes in patients with alcohol-related neurological changes.
Co-Authors Akmal Axmadjonovich, Gaybiyev Bobir Temirpulotovich, Turayev Malikaxon Mirxamzayevna, Mamurova Shuxrat Toshtemirovich, Niyozov