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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Vitaly Sergeevich, Sedenkov
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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CLINICAL AND DYNAMIC CHARACTERISTICS IN THE COMORBID COURSE OF ALCOHOL DEPENDENCE AND AFFECTIVE DISORDERS Vitaly Sergeevich, Sedenkov; Shoxrux Xabibullayevich, Sultanov; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1204

Abstract

Objective: This study aims to investigate the clinical and dynamic characteristics of the comorbid course of alcohol dependence and affective disorders, focusing on the relationship between harmful alcohol consumption and mental health conditions such as anxiety, depression, self-harm, and suicidal behavior. Method: An evidence-based review was conducted, analyzing data from clinical studies, epidemiological reports, and psychiatric assessments to explore the associations between alcohol dependence and affective disorders. The review included comparative analyses of patient histories, diagnostic criteria, and treatment outcomes. Results: The findings indicate a strong correlation between harmful alcohol use and the prevalence of affective disorders, with alcohol dependence significantly increasing the risk of anxiety, depressive symptoms, and suicidal tendencies. However, the causal pathways underlying these associations remain complex and multifactorial, influenced by genetic, neurobiological, and psychosocial factors. Novelty: This study highlights the critical need for integrated treatment models that address both alcohol dependence and co-occurring affective disorders, offering new insights into the development of comprehensive therapeutic strategies aimed at improving mental health outcomes in individuals with dual diagnoses.
CHARACTERISTIC FEATURES OF THE COMORBID COURSE OF ALCOHOLISM AND SCHIZOAFFECTIVE DISORDERS Vitaly Sergeevich, Sedenkov; Shoxrux Xabibullayevich, Sultanov; Bobir Temirpulotovich, Turayev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 1 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i1.1205

Abstract

Objective: This study aims to investigate the characteristic features of the comorbid course of alcoholism and schizoaffective disorders, focusing on the interplay between neurobiological mechanisms and clinical outcomes in patients with dual diagnoses. Method: A comprehensive review of clinical data and neurobiological studies was conducted, analyzing treatment approaches and the convergence of pathophysiological processes in patients with co-occurring alcohol dependence and schizoaffective disorders. Particular attention was given to the role of the dynorphin kappa-opioid system as a modulator of mesocorticolimbic dopaminergic system activity, which is implicated in both mental disorders and substance addiction. Results: The findings indicate that comorbid patients exhibit more severe clinical symptoms, poorer prognoses, and reduced treatment efficacy compared to individuals with singular diagnoses. The dysregulation of the dynorphin kappa-opioid system contributes to the exacerbation of both psychotic and addictive symptoms, complicating therapeutic interventions. Novelty: This study highlights the critical role of the dynorphin kappa-opioid system as a universal modulator in the pathogenesis of schizoaffective disorders and alcoholism, emphasizing the need for integrated treatment strategies that target both neurobiological and clinical dimensions of comorbidity.
Co-Authors Bobir Temirpulotovich, Turayev Shoxrux Xabibullayevich, Sultanov