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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
M.O, Djuraev
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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ASSESSMENT OF HIP JOINT ENDOPROSTHESIS TREATMENT EFFECTIVENESS AND ITS IMPACT ON PATIENTS' QUALITY OF LIFE Y.U., Joynarov; N.R, Ishburiev; U.M, Shermatov; Z.Sh, Abulfayzov; M.O, Djuraev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1335

Abstract

Objective: This study investigates the effectiveness of total hip arthroplasty (THA) in restoring joint function and enhancing the overall quality of life for patients with severe hip joint disorders. Method: Conducted at the Department of Traumatology and Orthopaedics, Surkhandarya Regional Multidisciplinary Medical Centre, Uzbekistan, the study observed 82 patients who underwent THA between 2022 and 2024. The Harris Hip Score and SF-36 health survey were used to evaluate patients’ physical function, pain levels, emotional state, and social well-being before surgery and at 3 and 12 months postoperatively. Results: Findings demonstrated a significant reduction in pain and substantial improvements in mobility, independence, and physical health indicators. Patients also reported enhanced mood, sleep quality, and life satisfaction, suggesting broad psychosocial benefits beyond physical rehabilitation. Novelty: Unlike prior studies focused solely on biomechanical outcomes, this research emphasizes the holistic impact of hip endoprosthesis, highlighting THA as not merely a mechanical intervention but a transformative procedure with profound implications for psychological well-being and quality of life. The study advocates for patient-centered orthopaedic care with integrated postoperative support.
MORPHOMETRIC CHANGES IN THE TESTIS AGAINST THE BACKGROUND OF CHEMOTHERAPY-INDUCED RENAL FAILURE AND THEIR BIOCORRECTION Y.U., Joynarov; N.R, Ishburiev; U.M, Shermatov; Z.Sh, Abulfayzov; M.O, Djuraev
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1336

Abstract

Objective: This study investigates the effects of chemotherapy-induced renal impairment on testicular morphology and evaluates the efficacy of a biocorrective intervention aimed at mitigating associated reproductive damage. Method: Conducted at the Department of Trauma Outcomes and Orthopaedics, Surkhandarya Multidisciplinary Medical Centre, the study utilized an animal model to simulate cytotoxic therapy-induced renal failure. Histological and morphometric analyses of testicular tissue were performed, focusing on parameters such as seminiferous tubule diameter, spermatogenic stratification, and interstitial cell function. A biocorrective agent with antioxidant properties was administered to assess restorative outcomes. Results: Chemotherapy-induced renal dysfunction resulted in significant structural alterations in the testes, including reduced spermatogenic activity and cellular degeneration. Treatment with the biocorrective compound led to partial restoration of testicular architecture and improved cellular integrity. Novelty: The study provides new insights into the systemic consequences of chemotherapy, particularly its underrecognized impact on male reproductive health, and demonstrates the therapeutic potential of targeted biocorrection in preserving gonadal function. These findings support a more integrative, organ-preserving approach in oncology care that prioritizes long-term quality of life alongside cancer eradication.
Co-Authors N.R, Ishburiev U.M, Shermatov Y.U., Joynarov Z.Sh, Abulfayzov