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All Journal Journal of Medical Genetics and Clinical Biology (JMGCB)
Fadhil , Haneen Husham
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing

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MCP-1 AND VITAMIN D PROFILES IN ESRD ON HEMODIALYSIS: A CASE-CONTROL STUDY IN AL-BASRAH CITY Fadhil , Haneen Husham; Salman , Rana Dawood; Hasan , Jubran Khaleel
Journal of Medical Genetics and Clinical Biology Vol. 2 No. 6 (2025): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v2i6.1340

Abstract

Objective: This study aimed to examine and compare serum levels of vitamin D and monocyte chemoattractant protein-1 (MCP-1) in patients with end-stage renal disease (ESRD) undergoing haemodialysis versus healthy individuals, and to evaluate their diagnostic potential as biomarkers. Method: An observational cross-sectional design was employed involving 30 ESRD patients receiving regular haemodialysis and 34 age- and sex-matched healthy controls. Serum levels of vitamin D, MCP-1, parathyroid hormone (PTH), urea, creatinine, estimated glomerular filtration rate (eGFR), and blood pressure were assessed. Results: ESRD patients showed significantly elevated levels of urea, creatinine, PTH, and MCP-1, and significantly lower eGFR and vitamin D levels compared to controls (p<0.001). ROC analysis revealed high diagnostic accuracy for PTH (AUC=0.946), with moderate-to-good performance for vitamin D (AUC=0.732) and MCP-1 (AUC=0.700). Novelty: This study contributes to the limited regional data by identifying the potential of vitamin D and MCP-1 as accessible clinical biomarkers for nutritional and inflammatory assessment in ESRD patients undergoing haemodialysis, emphasizing their role in early detection strategies and patient monitoring.
Co-Authors Hasan , Jubran Khaleel Salman , Rana Dawood