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All Journal SCIENTIA JOURNAL PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Antonius Fransiskus Putra Meliala
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Medicine & Pharmacology Nursing Public Health

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Uji Efektifitas Daun Kemangi (Ocium basilicum L.) Terhadap Pertumbuhan Bakteri Staphylococcus aureus Antonius Fransiskus Putra Meliala
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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The present study investigates the antibacterial efficacy of basil leaves (Ocimum basilicum L.) against the growth of Staphylococcus aureus, a Gram-positive bacterium responsible for various human infections. The increasing resistance of S. aureus to conventional antibiotics has necessitated the exploration of plant-based alternatives with potential antimicrobial activity. Basil leaves are known to contain active phytochemical constituents such as flavonoids, tannins, saponins, and essential oils that may contribute to antibacterial properties. An experimental laboratory study was conducted using a completely randomized design, employing various concentrations of basil leaf extract (10%, 20%, 40%, 80%) tested against S. aureus through the disc diffusion method. Chloramphenicol was used as the positive control, and sterile distilled water as the negative control. The results demonstrated a concentration-dependent antibacterial activity, with the 80% extract exhibiting the largest inhibition zone, though still lower than the zone produced by chloramphenicol. The data were analyzed using one-way ANOVA followed by post hoc Tukey test, indicating significant differences (p < 0.05) among the treatment groups. The findings confirm that basil leaf extract possesses antibacterial activity against Staphylococcus aureus, supporting its potential as a natural antimicrobial agent. These results offer preliminary evidence for the development of phytotherapeutic alternatives in combating bacterial infections, particularly in light of rising antibiotic resistance.
Histologi Kardiovaskular pada Wistar Diabetes Melitus Tipe 2 dengan Curcuma Zedoria Antonius Fransiskus Putra Meliala; Christopher Lawrence; Andreas Xaverio Bangun; Sondang Silitonga
SCIENTIA JOURNAL Vol. 13 No. 1 (2024): SCIENTIA JOURNAL
Publisher : Universitas Adiwangsa Jambi

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Type 2 Diabetes Mellitus (T2DM) can cause significant cardiovascular damage, including diabetic cardiomyopathy and diabetic vasculopathy, associated with increased oxidative stress and inflammation. This study aimed to evaluate the effect of Curcuma zedoaria extract on the improvement of heart and aorta histopathology in Wistar rats with T2DM. C. zedoaria extract was administered orally at doses of 100, 200, and 400 mg/kgBW for 6 weeks. The results showed that administration of C. zedoaria extract significantly reduced heart fibrosis and aortic elastin fragmentation, particularly at the 400 mg/kgBW dose. These findings suggest that C. zedoaria has potential as an adjunctive therapy to prevent cardiovascular damage in T2DM, with mechanisms involving the inhibition of oxidative stress and inflammation.
Co-Authors Andreas Xaverio Bangun Christopher Lawrence Sondang Silitonga