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All Journal Journal of Agromedicine and Medical Sciences Journal of Indonesian Medical Laboratory and Science (JoIMedLabS)
Muhammadiy, Noer Sidqi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology

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Association Between HbA1c Level and Renal Function Markers in Patients with Diabetes Mellitus Muhammadiy, Noer Sidqi; Purniawan, Luki Herli; Afthoni, Muhammad Hilmi
Journal of Indonesian Medical Laboratory and Science Vol 6 No 2: Oktober 2025
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v6i2.300

Abstract

Background: Diabetes mellitus (DM) is a major contributor to kidney failure worldwide. Glycated haemoglobin (HbA1c) is widely recognised as a marker for glycemic regulation, yet its association with renal function decline is not fully clarified. Objective: This study investigates the association between HbA1c levels and renal function indicators, namely creatinine, urea, and microalbumin, in individuals with DM. Materials and Methods: A cross-sectional approach was utilised, analysing retrospective data collected from the medical records of DM patients participating in the Prolanis program in Bondowoso Regency during 2024. Correlation tests and linear regression were used to determine the relationship between HbA1c and the selected renal parameters, with a statistical significance threshold of p < 0.05. Results: Most patients exhibited HbA1c levels and renal parameters within normal limits. Nonetheless, a statistically significant positive correlation was identified between elevated HbA1c levels and increased concentrations of creatinine (p = 0.020), urea (p = 0.01), and microalbumin (p = 0.01). Conclusion: Higher HbA1c levels are associated with deteriorating kidney function among DM patients. However, HbA1c should not be solely relied upon as a standalone marker for renal impairment. Further investigations are necessary to elucidate the biological pathways involved and to evaluate the potential of HbA1c control in mitigating kidney disease progression.
Occult Hepatitis B infection (OBI) in Indonesia: A Systematic Review Muhammadiy, Noer Sidqi; Senjarini, Kartika; Fajrin, Fifteen Aprila; Velavan, Thirumalaisamy P.; My, Truong Nhat; Song, Le Huu
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53733

Abstract

Hepatitis B Virus (HBV) infection remains a significant global health concern, with various genotypes exhibiting distinct clinical characteristics. Occult hepatitis B infection (OBI) is a latent form of HBV infection that is difficult to detect and poses a risk of transmission, particularly among high-risk populations such as blood donors, hemodialysis patients, and kidney transplant recipients. In Indonesia, studies on HBV genotype diversity and OBI prevalence remain limited, highlighting the need for a systematic analysis better to understand genotype distribution and its implications for public health. This systematic review was conducted using the PRISMA guidelines. Literature searches were performed on Google Scholar, Springer, ResearchGate, ScienceDirect, and PubMed using keywords related to OBI, HBV genotypes, and the Indonesian population. Studies that met the inclusion criteria were analyzed to assess genotype distribution and OBI prevalence. Among 352 screened articles, 35 studies met inclusion criteria. Genotypes B and C were identified as predominant HBV strains, with regional distribution variations. The highest OBI prevalence was recorded in eastern Indonesia (13.03%), followed by central (4.31%) and western (3.36%) regions. Nested PCR was the primary detection method for OBI. The predominance of genotype C in eastern Indonesia may contribute to higher OBI prevalence, emphasizing the need for region-specific diagnostic and management strategies. Further research is necessary to elucidate the association between HBV genotypes and clinical outcomes in OBI patients.
Co-Authors Fifteen Aprila Fajrin Kartika Senjarini My, Truong Nhat Purniawan, Luki Herli Song, Le Huu Velavan, Thirumalaisamy P.