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All Journal East Asian Journal of Multidisciplinary Research (EAJMR)
Kusumawati, Mulyaningtyas Ayu
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Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering

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Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) of Curcumin with D-Optimal Mixture Design Method Kusumawati, Mulyaningtyas Ayu; Iswandi, Iswandi; Kuncahyo, Ilham
East Asian Journal of Multidisciplinary Research Vol. 3 No. 11 (2024): November 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i11.12051

Abstract

Curcumin, known for its anti-inflammatory, antibacterial, anticarcinogenic, and antioxidant properties, faces challenges due to poor water solubility and low bioavailability as a BCS class II compound. The study investigates using a self-nanoemulsifying drug delivery system (SNEDDS) to enhance these properties, optimizing the formulation with the D-Optimal Mixture Design method. Sixteen formulas were prepared using oleic acid, Tween 80, and PEG 400. Each formula was characterized by particle size, % transmittance, emulsification time, and drug loading. The optimized formula, containing 10% oleic acid, 70% Tween 80, and 20% PEG 400, achieved a particle size of 80.167 nm, an emulsification time of 39.36 seconds, near 100% transmittance, and high drug loading.
Co-Authors Ilham Kuncahyo, Ilham Iswandi Iswandi