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All Journal Duta Pharma Journal Journal of Pharmaceutical and Sciences.
Wicahyo , Septian Maulid
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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AKTIVITAS ANTIHIPERGLIKEMI DAN REGENERASI SEL β PANKREAS DARI FRAKSI ETIL ASETAT DAUN KERSEN (Muntingia calabura) PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN PRATAMA, KHARISMA; Wicahyo , Septian Maulid; Hidayat, Rahmad
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v4i1.3818

Abstract

Normal blood glucose levels and antioxidant activity are the keys to preventing Diabetes Mellitus and its complications. Some herbal plants have this activity. Cherry leaves (Muntingia calabura) are plants around us that have empirical uses, one of which is lowering blood glucose. The aim of the research was to determine the activity of the ethyl acetate fraction of cherry leaves in reducing blood glucose and improving pancreatic beta cells. Forty-two 8-week-old male Wistar rats weighing 180-200 g were induced with diabetes using streptozotocin and divided randomly. Group I was normal control, group II was negative control, control III was positive control using glibenclamide, groups IV and V tested ethyl acetate fractions 250 and 350 mg/kg BW. Treatment is carried out orally once a day for 18 days. Glucose levels were measured on days 1, 4, 11 and 18. The results showed that the extract and fractions could reduce blood glucose levels with the 350 mg/kg BW ethyl acetate fraction reducing the highest (not significantly different from the positive control) and both could increase the activity of the SOD, GPx enzymes and reduce MDA levels and improve pancreatic Langerhans islets. In conclusion, cherry leaf extract and fractions have antihyperglycemic activity and pancreatic islet regeneration.
Optimasi Sediaan Serum Antiaging Ekstrak Etanol Rambut Baby Corn (Zea mays L.) Dwi Septyani, Vika Rizky; Wicahyo , Septian Maulid; Raharjo , Danang
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.622

Abstract

Skin is one of the organs that serve to protect the body from external influences. Exposure to free radicals causes skin damage, so antioxidant compounds are needed. Baby corn (Zea mays L.) hair contains flavonoids that have the potential to be antioxidants so that they can be formulated into an optimum serum preparation. This experimental study aims to determine the optimal formula concentration and antioxidant activity of anti-aging serum preparation of ethanol extract of Hair (Zea Mays L.). The optimum formula was obtained from the data analysis of Design Expert 13 Simplex Lattice Design method with variations in the concentration of Karbopol and TEA. The results showed that the variation of Karbopol and TEA concentrations affected the physical quality evaluation. The desirability value was 0.903, and the optimum formula concentration was obtained at Karbopol 1.7795% and TEA I2.294%. Data analysis of the optimum formula using the Shapiro-Wilk Normality Test and One Sample T-Test Test resulted in normally distributed data and no significant difference with the predicted value. The antioxidant activity test result of the optimum formula was 65.08 μg/ml with a strong category.
Co-Authors Dwi Septyani, Vika Rizky Pratama, Kharisma Raharjo , Danang