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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Pharmaceutical and Sciences.
Setiawardani, Maria Fitri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Pasien Kanker Payudara yang Menerima Terapi Tamoxifen di Dua Rumah Sakit Swasta di Jawa Tengah: Profil Sosiodemografi, Klinis, dan Pengobatan Setiawardani, Maria Fitri; Cholisoh, Zakky; Hapsari, Pramudita Mila
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1114

Abstract

Breast cancer is one of the most common types of cancer, including in Central Java Province, Indonesia, which reports a high incidence. The number of cases continues to increase, likely due to low public awareness of breast self-examination (BSE), limited health education, and a lack of motivation to undergo regular check-ups. One of the main treatment options is hormonal therapy, with Tamoxifen being the most widely used drug. To date, there is limited data on the sociodemographic and clinical characteristics among breast cancer patients who use Tamoxifen in Central Java. This information is essential for improving patient care and treatment strategies. This study aimed to describe the sociodemographic and clinical characteristics of breast cancer patients who received Tamoxifen at two private hospitals in Central Java. The results showed that most patients were under 50 years old (66%), had a low level of education (65.2%), and were employed (34.8%). Clinically, most patients were in advanced stages (56.5%), had no comorbidities (89.7%), and were not taking other medications (85%). These findings provide an initial overview of the profile of breast cancer patients using tamoxifen at two private hospitals in Central Java. However, these results cannot be generalized to the entire Central Java region due to the limitations of the study locations. Further studies with a broader scope are needed to obtain more representative data.
Adherence and Predictors of Endocrine Therapy Use Among Breast Cancer Patients in a Private Hospital: A Cross-Sectional Study Setiawardani, Maria Fitri; Cholisoh, Zakky; Hapsari, Pramudita Mila
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 2026: IN PRESS ISSUE (JUST ACCEPTED MANUSCRIPT)
Publisher : Universitas Airlangga

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Abstract

Background: Breast cancer has a high incidence rate. One of the treatments involves long-term endocrine therapy, which can cause boredom in patients with cancer, leading to non-compliance with therapy. Objective: This study aimed to evaluate adherence and identify the variables that affect the level of adherence in patients with breast cancer receiving endocrine adjuvant therapy at a private hospital in Central Java. Methods: This cross-sectional study used purposive sampling. Data were collected from 87 respondents in total. Data were collected using questionnaires and patient medical records. Results: We categorised the patient adherence level as adherent (65.5 %) and non-adherent (34.5 %). The logistic regression test revealed a relationship between adherence and education level (p-value=0.001; OR=0.056; 95% CI 0.012-0.281), stage (p-value=0,002; OR 0.096; 95% CI 0.022-0.424), and other medication use (p-value=0,020; OR=0.061; 95% CI 0.006-0.650). This indicates that education level, cancer stage, and other medication use significantly influenced the adherence rate of patients receiving endocrine adjuvant therapy. These findings emphasise the need for targeted educational support and optimised medication management to improve adherence among patients undergoing long-term endocrine therapy.
Co-Authors Cholisoh, Zakky Hapsari, Pramudita Mila