Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Pharmaceutical Reports
Basiru, Aliyu
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Antimicrobial Activity of Chemically Modified Anionic Azo Dyes and Their Potential for Treating Infectious Diseases Mohammed, Aliyu Danmusa; Basiru, Aliyu
Pharmaceutical Reports Vol 4, No 2 (2025): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v4i2.353

Abstract

This study explores the synthesis, characterization, and antimicrobial evaluation of quaternary ammonium salts (QAS) and silver nanoparticles (AgNPs) incorporated with azo dyes—Sunset Yellow, Tartrazine, and Allura Red. FTIR spectroscopic studies confirmed key functional groups and interactions, including azo (–N=N), C=C, and hydroxyl stretches, indicating successful conjugation between dyes and carrier materials. The antimicrobial activities of these compounds were assessed against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Salmonella spp. Results revealed enhanced inhibition zones, particularly for the dye incorporated with siver nanoparticles (dye-AgNPs) combinations, with Tartrazine + AgNPs (B2) showing the highest efficacy against S. aureus. Quaternary ammonium salts alone displayed moderate activity, while their combinations with azo dyes yielded improved bacterial inhibition, especially against Gram-positive strains. The enhanced antimicrobial performance is attributed to increased lipophilicity and better penetration of bacterial membranes due to dye incorporation. Furthermore, the research highlights the potential use of azo dye-functionalized QAS and AgNPs as effective antimicrobial agents, especially in targeting resistant Gram-positive pathogens.
Co-Authors Mohammed, Aliyu Danmusa