Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal MASALIQ: Jurnal Pendidikan dan Sains Asian Journal of Science, Technology, Engineering, and Art
Blessed, Akpor Ugochukwu
Unknown Affiliation
Religion Arts Computer Science & IT Education Engineering Social Sciences

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Biochemical Integration of Chemically Modified Carbon Nanotubes Blessed, Akpor Ugochukwu
MASALIQ Vol 5 No 5 (2025): SEPTEMBER
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i5.7459

Abstract

Carbon nanotubes (CNTs) have attracted growing interest in recent years for their small size, ordered structure, and distinctive surface and atomic configurations that enable applications across biomedicine and materials science. The objective of this study is to synthesize current knowledge on CNTs, how they are defined, classified, arranged, and synthesized; their unique properties; and their applications and risks with emphasis on drug delivery and broader biomedical uses. Methodologically, the paper conducts a literature-based review of CNT properties and uses, including their roles as carriers for therapeutic molecules (e.g., peptides), biosensors, and components in molecular electronics and composite materials, as well as hazards, regulatory considerations, and medical status. Key findings indicate that CNTs are promising, biocompatible, and supportive materials for transporting therapeutics owing to their internal cavity and ease of coating with biocompatible chemicals; they can be readily taken up by cell membranes and have been reported to deliver drugs directly to cancer cells. Beyond biomedicine, CNTs’ structural and surface features support their application as biosensors and in molecular electronics and composite formulations. The study concludes that CNTs offer substantial potential for targeted drug delivery and multimodal biomedical uses while requiring careful consideration of hazards and regulatory frameworks. The contribution and implication are a consolidated overview that highlights largely untapped opportunities for CNTs in biological research and clinical translation alongside the need for systematic evaluation of safety and oversight.
Antiplasmodial and Haem Transition Activities of Tannin and Glycoside Fractions of Phyllanthus amarus Blessed, Akpor Ugochukwu
Asian Journal of Science, Technology, Engineering, and Art Vol 3 No 5 (2025): Asian Journal of Science, Technology, Engineering, and Art
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstea.v3i5.7460

Abstract

Malaria remains a major public health threat, particularly in Nigeria, amid rising resistance of Plasmodium falciparum to existing therapies, underscoring the need for new, effective, and affordable antimalarials. This study aimed to evaluate the antiplasmodial activity of Phyllanthus amarus tannin and glycoside extracts and to assess their effects on haem-related mechanisms. Standard procedures were used to prepare crude extracts, which were tested against sensitive P. falciparum 3D7 strains; parasite growth inhibition and haem transition inhibition assays were conducted, and performance was benchmarked against chloroquine. Key findings show that the tannin extract reduced parasite growth (albeit less than chloroquine, p < 0.05) with IC₅₀ = 3.09 µg/mL, whereas the glycoside extract exhibited minimal activity (IC₅₀ = 14.45 µg/mL) compared with chloroquine (IC₅₀ = 0.41 µg/mL). Neither extract significantly inhibited haem transition, in contrast to chloroquine, suggesting possible interference at early stages of haem oligomerisation while haem remains in solution. The study concludes that the tannin extract demonstrates promising antiplasmodial activity, while the glycoside extract does not. The contribution and implication are that the antimalarial properties of P. amarus observed in vitro and in vivo may be partly attributable to its tannin content, warranting further investigation as a candidate for antimalarial development.
Co-Authors