Yurista, Salva Reverentia
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Is Targeting Inflammation the Key to Unlocking HFpEF?: Focus on anti-inflammatory therapy Yurista, Salva Reverentia; Sargowo, Djanggan
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.1

Abstract

Chronic inflammation plays a crucial role in the formation of atherosclerosis and is also associated with the advancement of heart failure. Clinical and epidemiological evidence has increasingly supported the link between low-grade inflammation and heart failure with preserved ejection fraction (HFpEF). From a fundamental scientific standpoint, inflammation in HFpEF has notable detrimental impacts on the endothelium and the microvasculature of the heart. HFpEF clinical studies focusing on inflammation are a sign of hope because they show a shift toward treating the condition's cause instead of just its symptoms.