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Determination of the Chemical Properties of Some Selected Vegetable Oils Sold in Gombe Main Market, Gombe State, Nigeria Goje, Lazarus Joseph; Muhammad, Muhammad Auwal; Maigari, Fatima Umar; Hammari, Abubakar Muhammad
Journal of Multidisciplinary Science: MIKAILALSYS Vol 3 No 2 (2025): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v3i2.6045

Vegetable oils are widely utilized as essential lipid sources in food production, necessitating routine evaluation of their nutritional and chemical quality. This study assessed the quality of four commonly consumed edible vegetable oil brands in Gombe, Gombe State: Palm oil (Al-Hilal), Turkey oil, Power oil, and Kings oil. Samples were collected from the Gombe main market and analyzed for saponification value, iodine value, and peroxide value. These parameters were compared against the standards set by the Standard Organization of Nigeria (SON). Turkey oil exhibited the lowest saponification value (192.43 ± 0.51 mg KOH/g), though all oils fell within the SON-recommended range of 185–205 mg KOH/g. The iodine values indicated low levels of unsaturated fatty acids across all samples, with palm oil showing the highest (15.29 ± 0.49 g) and Turkey oil the lowest (6.61 ± 0.63 g). Peroxide values for all samples were well below the 10 meq/kg threshold for rancidity, indicating freshness and stability. Overall, the results demonstrate that all vegetable oil samples met the quality standards set by SON and the Nigerian Industrial Standard (NIS). It is therefore concluded that the oils are unadulterated, of high quality, and safe for public consumption, reflecting proper processing and storage practices.

Determination of Mechanism of Resistance to Pyrethroid by Anopheles gambiae sensu lato from Gombe State, Nigeria Yusuf, Asama’u; Goje, Lazarus Joseph; Mafulul, Simon Gabriel; Garba, Nabiha; Abubakar, Nura
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 1 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i1.5023

The emergence of insecticide resistance in Anopheles gambiae sensu lato poses a significant challenge to malaria control efforts, particularly in endemic regions like Gombe, Nigeria. This study aimed to investigate the mechanisms underlying pyrethroid resistance and identify the prevalent Anopheles species in the area. Morphological identification was performed using keys from Gille and Coetzee, confirmed by molecular techniques employing SINE200 PCR for precise species characterization. The results revealed that the An. gambiae complex comprised 75% of the mosquito population, indicating its dominance in the region. Knockdown rate bioassays demonstrated a time-dependent increase in resistance to insecticides, with notable exceptions observed with deltamethrin. Susceptibility testing conducted 24 hours post-exposure confirmed that the population exhibited resistance to all tested insecticides, with DDT showing the highest resistance level. Molecular analysis identified Anopheles coluzzii as the most prevalent species in Gombe, followed by An. arabiensis. Additionally, the prevalence of kdr alleles was assessed, revealing a significant correlation between the L1014F mutation and resistance phenotypes. Specifically, the frequency of the L1014F allele was linked to increased resistance levels, while the homozygous susceptible allele was also prevalent, suggesting the potential influence of other resistance mechanisms. In conclusion, this study highlights the critical need for ongoing surveillance of insecticide resistance in Anopheles gambiae populations. It underscores the importance of understanding the genetic basis of resistance to inform effective vector control strategies. The findings emphasize that adaptive management of insecticide use, considering the dynamics of resistance and species composition, is essential for enhancing malaria control efforts in Gombe and similar regions.

The Role of Telomeres and Telomerase in Cellular Aging and Disease: Mechanisms, Implications, and Therapeutic Interventions Christopher, Grace; Goje, Lazarus Joseph
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5151

Telomeres, the protective caps at the ends of chromosomes, play a crucial role in maintaining genomic stability. This review explores the structure and function of telomeres, the mechanisms of telomere shortening, and the role of telomerase in counteracting this process. Telomere shortening is a natural consequence of cell division and is associated with cellular aging, senescence, and apoptosis. The review delves into the molecular biology of telomeres, highlighting the significance of the shelterin complex in protecting telomeres from degradation and fusion. It also discusses the genetic and epigenetic factors influencing telomere length, the impact of oxidative stress and inflammation on telomere attrition, and potential interventions to preserve telomere length. The review concludes with recommendations for lifestyle changes and therapeutic strategies to mitigate telomere shortening and promote healthy aging.

Determination of Mechanism of Resistance to Pyrethroid by Anopheles gambiae sensu lato from Gombe State, Nigeria Yusuf, Asama’u; Goje, Lazarus Joseph; Mafulul, Simon Gabriel; Garba, Nabiha; Abubakar, Nura
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 1 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i1.5023

The emergence of insecticide resistance in Anopheles gambiae sensu lato poses a significant challenge to malaria control efforts, particularly in endemic regions like Gombe, Nigeria. This study aimed to investigate the mechanisms underlying pyrethroid resistance and identify the prevalent Anopheles species in the area. Morphological identification was performed using keys from Gille and Coetzee, confirmed by molecular techniques employing SINE200 PCR for precise species characterization. The results revealed that the An. gambiae complex comprised 75% of the mosquito population, indicating its dominance in the region. Knockdown rate bioassays demonstrated a time-dependent increase in resistance to insecticides, with notable exceptions observed with deltamethrin. Susceptibility testing conducted 24 hours post-exposure confirmed that the population exhibited resistance to all tested insecticides, with DDT showing the highest resistance level. Molecular analysis identified Anopheles coluzzii as the most prevalent species in Gombe, followed by An. arabiensis. Additionally, the prevalence of kdr alleles was assessed, revealing a significant correlation between the L1014F mutation and resistance phenotypes. Specifically, the frequency of the L1014F allele was linked to increased resistance levels, while the homozygous susceptible allele was also prevalent, suggesting the potential influence of other resistance mechanisms. In conclusion, this study highlights the critical need for ongoing surveillance of insecticide resistance in Anopheles gambiae populations. It underscores the importance of understanding the genetic basis of resistance to inform effective vector control strategies. The findings emphasize that adaptive management of insecticide use, considering the dynamics of resistance and species composition, is essential for enhancing malaria control efforts in Gombe and similar regions.

The Role of Telomeres and Telomerase in Cellular Aging and Disease: Mechanisms, Implications, and Therapeutic Interventions Christopher, Grace; Goje, Lazarus Joseph
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5151

Telomeres, the protective caps at the ends of chromosomes, play a crucial role in maintaining genomic stability. This review explores the structure and function of telomeres, the mechanisms of telomere shortening, and the role of telomerase in counteracting this process. Telomere shortening is a natural consequence of cell division and is associated with cellular aging, senescence, and apoptosis. The review delves into the molecular biology of telomeres, highlighting the significance of the shelterin complex in protecting telomeres from degradation and fusion. It also discusses the genetic and epigenetic factors influencing telomere length, the impact of oxidative stress and inflammation on telomere attrition, and potential interventions to preserve telomere length. The review concludes with recommendations for lifestyle changes and therapeutic strategies to mitigate telomere shortening and promote healthy aging.

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