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All Journal Jurnal Ners Indonesian Journal of Cancer
Hafiz, Muhammad Zaki Abdul
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Mutation of BRCA1/2 Gene in Premenopausal Triple-Negative Breast Cancer Patients in West Sumatera Harahap, Wirsma Arif; Khambri, Daan; Panigoro, Sonar Soni; Hafiz, Muhammad Zaki Abdul
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1255

Abstract

Background: The BRCA1/2 mutation rate was found to be higher in triple-negative breast cancer (TNBC) patients depending on young age, and the presence of a family history of breast cancer and ovarian cancer. Research on BRCA1/2 germline mutations that focused on premenopausal TNBC patients in Indonesia has never been carried out. The objective of this research is to determine the BRCA1/2 germline gene mutation status in premenopausal TNBC patients in West Sumatra.Methods: This is a descriptive study conducted at the Surgical Oncology Division of DR. M. Djamil Hospital, Padang from April to July 2023. This study included patients aged 50 years who were diagnosed with the TNBC subtype at Dr. M. Djamil Hospital, Padang from January 2016 to July 2023. Secondary data was collected through the patient’s medical records to observe the TNBC patient’s characteristics. A blood test of TNBC patients was carried out to determine germline mutation of BRCA1/2.Results: 22 patients with TNBC participated in the study. In this study, 4/22 (18.2%) had BRCA2 pathogenic mutations and no BRCA1 pathogenic mutation was found. All patients with BRCA2 pathogenic mutation have the same mutation characteristics, i.e exon 3, genetic variation (c.262_263delCT), amino acids (p.Leu88AlafsTer12), and type of mutation (Frameshift Deletion). Conclusions: TNBC patients in West Sumatra have BRCA2 pathogenic mutations with the same characteristics as the mutations
Subplatysmal Flap Reconstruction After Hemiglossectomy and Radical Neck Dissection for Tongue Squamous Cell Carcinoma in low-resource settings Syukri, Fahreza; Hafiz, Muhammad Zaki Abdul; Valentino, Andrea; Tripriadi, Effif Syofra; Bunawir, Fathar Usman; Salamullah, Muhammad; Maulanisa, Sinta Chaira
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.55488

Abstract

Background: Squamous cell carcinoma (SCC) of the tongue exhibits aggressive local behavior and a high propensity for early cervical lymphatic metastasis. The routine management of locally advanced disease consists of hemiglossectomy with radical neck dissection followed by primary reconstruction. In many low-resource settings, microvascular free flaps may not be feasible due to limited infrastructure, prolonged operative times, or patient comorbidities. The subplatysmal flap offers a practical, time-efficient alternative in such circumstances. Case Presentation: We report a 71-year-old male with stage T3N2bM0 tongue SCC who underwent hemiglossectomy and ipsilateral RND, followed by immediate reconstruction using a subplatysmal flap harvested from the anterior cervical triangle. The flap provided adequate coverage, excellent viability, and satisfactory functional recovery, with no major postoperative complications. Conclusion: The subplatysmal flap is relatively safe and oncologically acceptable as well as functionally efficient method for moderate-size tongue defect, especially for older age or comorbid patient and non-microsurgical center.
Co-Authors Bunawir, Fathar Usman Daan Khambri Effif Syofra Tripriadi, Effif Syofra Maulanisa, Sinta C. Salamullah, Muhammad Sonar Soni Panigoro Syukri, Fahreza Valentino, Andrea Wirsma Arif Harahap