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Imran, Arlan
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Agriculture, Biological Sciences & Forestry Chemistry

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PHARMACOKINETIC PROFILE OF SNEDDS PREPARATION EXTRACT OF PUTRI MALU LEAVES Imran, Arlan; Nur’ainun Panigoro; Iksandi Aliwu; Melis Ma’ruf; Rajid Mbuinga
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2897

Abstract

The Indonesian Ministry of Health reported that incidence of hepatitis in Indonesia has reached 20 million cases. As one of the preventive to reduce hepatitis disease, by consuming natural hepatoprotectors Putri malu plant. Therefore, Putri Malu needs to increase its bioavaibility in the body by making SNEDDS preparations. Purpose of this research is to knowing the formulation of variations in the concentration of oil, surfactant and cosurfactant in the preparation of SNEDDS Putri malu leaf extract on pharmacokinetics including Cpmax, Tmax and T1/2 values. Research method is a laboratory experimental by varying the concentration of VCO: Tween 80: PEG 400, namely F1 (1:6:3), F2 (1:7:2) and F3 (1:8:1). Results : formulation of the SNEDSS of Putri malu leaves has nanoemulsion times at F1-F3 each 3.65, 14.78 and 25.61 seconds. The Cpmax value of the third formula gets a value of 500 ppm, Tmax the three formulas get the same Tmax value of 0 hours and for the T1/2 value at F1-F3 each 4.222, 6836, and  2.826 hours. The best formula is found F2, this can be seen at T1/2, the longer the drug can last in the body, the less frequency of taking the drug.
QUERCETIN AND PIPERINE CONTENT OF FRACTION N-HEXANE : ETHYL ACETATE SESEWANUA LEAF (CLERODENDRUM FRAGRANS WILD.) Imran, Arlan; Zulfiayu; Ahmad Aswad
JURNAL KATALISATOR Vol. 10 No. 1 (2025): Jurnal Katalisator ( On Progres)
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i1.3403

Abstract

Sesewanua (Clerodendrum fragrans Wild.) is used as an anti-inflammatory (anti-rheumatoid arthritis) topically and orally and as an antioxidant with very strong potential. The n-hexane fraction: ethyl acetate of sesewanua leaves contains secondary metabolites of flavonoids and alkaloids. This study aimed to measure the levels of the flavonoid quercetin and the levels of the alkaloid piperine in the n-hexane: ethyl acetate fraction of the ethanol extract of sesewanua leaves. This research method: The n-hexane:ethyl acetate fraction was determined for its flavonoid content at a wavelength of 256 nm and piperine alkaloids at a wavelength of 342.5 nm using the UV-Vis spectrophotometry method. The results obtained from the n -hexane:ethyl acetate fraction of the ethanol extract of sesewanua leaves contained the flavonoid compound quercetin as much as 6.385 PPM and the alkaloid compound piperine as much as 5.854 PPM. Conclusion: The statistical results of the Independent T. Test show that there are significant levels of the flavonoid quercetin and alkaloid piperine, which means that the levels of the flavonoid quercetin in the n-hexane: ethyl acetate fraction of the ethanol extract of sesewanua leaves are higher than the alkaloid piperine compound.
Co-Authors Ahmad Aswad Iksandi Aliwu Melis Ma’ruf Nur’ainun Panigoro Rajid Mbuinga Zulfiayu