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All Journal International Journal of Applied Biology
Poddar, Anirban
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Agriculture, Biological Sciences & Forestry Automotive Engineering Energy Environmental Science

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Adenosine Deaminase Activity in Serum of Diabetics: A Reflection of Glycemic Profile? Poddar, Anirban; De, Devyani
International Journal of Applied Biology Vol. 7 No. 1 (2023): International Journal of Applied Biology
Publisher : Hasanuddin University

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Abstract

Diabetes presents with a constellation of symptoms,hyperglycemia being just one of them.The primary challenge faced by physicians is to achieve a control over this exorbitant blood sugar levels.Oral antidiabetic agents & insulin therapy are the primary modalities of treatment available presently. The most reliable diagnostic as well as prognostic marker used for this purpose is HbA1c. Adenosine Deaminase (ADA), an enzyme associated with purine metabolism is known to exert potent metabolic effects through its receptors. ADA is primarily an established inflammatory marker reflecting T lymphocyte activity .Adenosine,the substrate of ADA is known to affect cholesterol synthesis in liver,thereby serving as a key hinge in the fine balance between glucose & lipid homeostasis. Due to the association of ADA with glucose & lipid homeostasis ,the authors believe that studying ADA activity in serum of diabetics can reveal many important facts which might open a new dimension in diagnosis & treatment protocol for diabetes mellitus.The purpose of our study was to monitor ADA activity in serum of diabetic patients who are on oral antidiabetic drugs & do not have evidence of microvascular or macrovascular complications of diabetes & also determine if any correlation exists between fasting blood glucose,HbA1c & serum ADA activity.
Transmissible Spongiform Encephalopathies & Prion Proteins: A Systematic Review Poddar, Anirban; Kundu, T. N.; Ray, Manaly Sinha; Maji, Rituparna
International Journal of Applied Biology Vol. 7 No. 2 (2023): International Journal of Applied Biology
Publisher : Hasanuddin University

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Prion proteins (PrPc) have been implicated as the causative agent of “Transmissible Spongiform Encephalopathies” (TSE). Apart from this devilish role, prions also have a bright facet of their own and their identity holds much more than just being a pathogenic entity. Role of prions as scaffolding proteins for ligand binding and signal transduction has been reported by several researchers. Role of prions in nerve impulse transmission at neuronal junctions, glyapse and gap junctions have been reported. Prion mediated regulation of calcium ion flux and redox status in turn regulates many major cellular functions. In this review we have focussed mainly on the physiological aspects of prion function apart from its pathological role in TSE. Role of prions in mediation of neuropathic pain, neuroinflammatory diseases and chronic headache has been reported by few researchers. In this review we have tried to correlate such effects of prions and also discuss various therapeutic targets for various diseases influenced by prions.
Co-Authors De, Devyani Kundu, T. N. Maji, Rituparna Ray, Manaly Sinha