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All Journal Jurnal Sehat Indonesia (JUSINDO) Innovative: Journal Of Social Science Research
Yanita, Bella
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Humanities Computer Science & IT Dentistry Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary Other

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Comparative Outcomes Of Laparoscopy-Assisted Vs. Open Distal Gastrectomy For Gastric Cancer In The Elderly: A Systematic Review Yanita, Bella; Wintoko, Rizal; Farishal, Ahmad
Innovative: Journal Of Social Science Research Vol. 4 No. 5 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i5.15309

Abstract

Abstract Background: Gastric cancer, prevalent among the elderly, presents considerable health challenges due to the age-related decline in immune function. Surgical management options include laparoscopic-assisted gastrectomy (LDG) and open gastrectomy (ODG). Methods: This systematic review followed PRISMA guidelines, using PubMed, Scopus, and Cochrane Library to identify cohort and case-control studies published between 2014–2024. Studies comparing LDG and ODG in patients aged 70 and older, reporting on outcomes such as recovery time, postoperative complications, and survival rates, were included. Data extraction and bias assessment were conducted, and a qualitative synthesis of results was performed. Results: LDG was associated with longer operating times compared to ODG in three out of five studies (p < 0.01). However, LDG consistently resulted in significantly lower intraoperative blood loss (p < 0.01) and faster recovery, evidenced by shorter time to first flatus and oral intake (p < 0.01) and reduced hospital stays across all studies (p < 0.05). LDG was associated with fewer postoperative complications in two studies (p < 0.05), although other studies showed no significant difference in complication rates. Discussion: Five retrospective cohort studies with a total of 317 LDG and 256 ODG were included in the qualitative analysis. LDG was associated with significantly reduced intraoperative blood loss, faster recovery times, and shorter hospital stays, making it a favorable option for elderly patients. While LDG generally involved longer operating times, it did not lead to increased postoperative complications. Conclusion: LDG offers several short-term advantages compared to ODG, suggesting it may be a safer and more effective approach for elderly gastric cancer patients. However, further studies are needed to assess long-term outcomes and confirm the overall efficacy of LDG in this population. Keywords: Gastric Cancer, Eldery Patients, Comparative, Systematic Review, Survival Rates
Sodium Zirconium Cyclosilicate Compared with Polystyrene Sulfonate for the Management of Hyperkalemia in Chronic Kidney Disease: A Systematic Review Yanita, Bella; Hutasoit, Januar Ishak
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 1 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i2.463

Abstract

Background: Hyperkalemia is a common and potentially life-threatening complication in patients with chronic kidney disease (CKD). Methods: This systematic review followed the PRISMA 2020 guidelines. A comprehensive literature search was conducted using PubMed, ScienceDirect, and the Cochrane Library to identify randomized controlled trials and comparative observational studies involving adult patients with CKD and hyperkalemia. Studies comparing sodium zirconium cyclosilicate (SZC) with polystyrene sulfonate–based binders and reporting efficacy or safety outcomes were included. Data extraction and risk of bias assessment were performed, and a qualitative synthesis of results was conducted due to study heterogeneity. Results: Eight studies were included in the qualitative analysis, comprising seven interventional and hospital-based observational studies involving 690 patients and one large nationwide cohort including more than 70,000 patients. In acute settings, SZC achieved rapid reductions in serum potassium, with greater or comparable efficacy to polystyrene sulfonate–based binders. In chronic management, SZC was associated with earlier normalization and more sustained potassium control. Safety outcomes were generally comparable, with favorable tolerability and patient preference observed for SZC. Discussion: The included studies consistently demonstrated effective potassium lowering with SZC across acute and chronic settings. While heterogeneity and the predominance of observational data limit causal inference, the overall findings support the clinical utility of SZC, particularly in facilitating long-term potassium control and treatment adherence. Conclusion: SZC represents an effective and well-tolerated alternative to polystyrene sulfonate–based binders for the management of hyperkalemia in patients with CKD. Further well-designed randomized studies are warranted to confirm long-term clinical benefits.
Co-Authors Farishal, Ahmad Hutasoit, Januar Ishak Wintoko, Rizal