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All Journal Journal of Tropical Pharmacy and Chemistry
Ahmed, Elhadi M. M.
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Evaluation of Acute and Repeated Dose Oral Toxicity of Phoenix dactylifera L. Pollen Methanolic Extract in Rats Abdelrahim, Musab A. M.; Ahmed, Elhadi M. M.
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.631

Abstract

Pollen of the date palm (Phoenix dactylifera L.) has been used for thousands of years as a traditional herbal medicine for improving fertility. However, safety of plant-derived materials is an important concern to human health, and herbal remedies should be taken with adequate knowledge about their toxicity, adverse effects, purity, appropriate dosage and dose limits. The current work was undertaken to evaluate the safety of date palm pollen (DPP) and to classify it according to its oral toxicity in rats. The experiments were done according to the reported guidelines of the Organization for Economic Co-operation and Development (OECD) to assess the acute and repeated dose oral toxicity in rats. The obtained results showed neither death nor sign of toxicity or abnormality in any of the animals throughout the experimental period regarding acute and repeated dose oral toxicity. Also the results of the hematological and clinical biochemistry determinations showed no significant differences between the control and DPP-treated rat groups. It could be concluded that, the tested plant material is a relatively safe substance and its approximate LD50 defined by 2000mg/kg < LD50 < 5000mg/kg according to the OECD tests guidelines.
Evaluation of Protective Role of Date Palm Pollen against Cisplatin-Induced Reproductive Toxicity in Rats Abdelrahim, Musab A. M.; Ahmed, Elhadi M. M.; Taj-Eldin, Imad M.; Mohammed, Abd-Elwahab H.
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.643

Abstract

Date palm pollen (DPP) is herbal mixture that widely used in traditional medicine to improve fertility. The current study aimed to determine the protective role of the DPP extract against cisplatin-induced reproductive toxicity in rats. Sixty rats were used (30 of each sex) and allocated to normal, negative, and test control groups of males and females (10 animals per group). Reproductive toxicity was induced by an intraperitoneal injection of cisplatin (4.5 mg/kg/72 hour) in the negative and test groups, whereas the test groups also received daily oral doses of DPP methanolic extract (250 mg/kg). At the end of the experimental period (30 days), the rats were sacrificed to determine the fertility parameters. The obtained results showed that, oral administration of DPP extracts exhibited protective effects as demonstrated by a prominent increase in serum estradiol concentration, recovery from reduction in gonads weight, and a considerable enhancement on histological observations among male and female rats. Moreover, elevation in epididymal sperm count and motility in male animals was observed compared to that in cisplatin-treated rats. DPP had a significant effect on estradiol levels, as well as protective effects against cisplatin-induced reproductive toxicity in both male and female rats. Keywords:          Cisplatin, date palm, epididymal characteristics, Phoenix dactylifera
Co-Authors Abdelrahim, Musab A. M. Mohammed, Abd-Elwahab H. Taj-Eldin, Imad M.